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Maintenance of muscle stem-cell quiescence by microRNA-489

Author

Listed:
  • Tom H. Cheung

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Navaline L. Quach

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Gregory W. Charville

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine
    Stanford University School of Medicine)

  • Ling Liu

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Lidia Park

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Abdolhossein Edalati

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Bryan Yoo

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Phuong Hoang

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Thomas A. Rando

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine
    Neurology Service, Veterans Affairs Palo Alto Health Care System
    Rehabiliitation Research and Development Center of Excellence, Veterans Affairs Palo Alto Health Care System)

Abstract

Adult muscle stem cells are used as a model system to show that the microRNA pathway, and specifically miR-489, is essential for the maintenance of the quiescent state of an adult stem-cell population by suppressing a key proliferation factor, Dek.

Suggested Citation

  • Tom H. Cheung & Navaline L. Quach & Gregory W. Charville & Ling Liu & Lidia Park & Abdolhossein Edalati & Bryan Yoo & Phuong Hoang & Thomas A. Rando, 2012. "Maintenance of muscle stem-cell quiescence by microRNA-489," Nature, Nature, vol. 482(7386), pages 524-528, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10834
    DOI: 10.1038/nature10834
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    Cited by:

    1. Wenshu Zeng & Lu Yue & Kim S. W. Lam & Wenxin Zhang & Wai-Kin So & Erin H. Y. Tse & Tom H. Cheung, 2022. "CPEB1 directs muscle stem cell activation by reprogramming the translational landscape," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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