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Clonal selection drives genetic divergence of metastatic medulloblastoma

Author

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  • Xiaochong Wu

    (Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Paul A. Northcott

    (Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Adrian Dubuc

    (Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Adam J. Dupuy

    (Molecular & Cellular Biology Program, The University of Iowa)

  • David J. H. Shih

    (Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Hendrik Witt

    (German Cancer Research Center (DKFZ), Hematology and Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany)

  • Sidney Croul

    (University Health Network Pathology, Arthur and Sonia Labatt Brain Tumour Research Centre, University of Toronto, Toronto, Ontario M5S 1A1, Canada)

  • Eric Bouffet

    (Brain Tumour Program, Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Daniel W. Fults

    (University of Utah School of Medicine)

  • Charles G. Eberhart

    (Johns Hopkins University)

  • Livia Garzia

    (Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Timothy Van Meter

    (Virginia Commonwealth University)

  • David Zagzag

    (New York University School of Medicine)

  • Nada Jabado

    (McGill University, Montreal H3Z 2Z3, Quebec, Canada)

  • Jeremy Schwartzentruber

    (McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 0G1, Canada)

  • Jacek Majewski

    (McGill University, Montreal H3Z 2Z3, Quebec, Canada)

  • Todd E. Scheetz

    (Molecular & Cellular Biology Program, The University of Iowa)

  • Stefan M. Pfister

    (German Cancer Research Center (DKFZ), Hematology and Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany)

  • Andrey Korshunov

    (University of Heidelberg, Im Neuenheimer Feld 220/221, 69120 Heidelberg, Germany)

  • Xiao-Nan Li

    (Brain Tumor Program, Texas Children’s Cancer Center, Baylor College of Medicine)

  • Stephen W. Scherer

    (Program in Genetics and Genomic Biology and The Centre for Applied Genomics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5S 1A1, Canada)

  • Yoon-Jae Cho

    (Stanford University School of Medicine)

  • Keiko Akagi

    (Immunology and Medical Genetics, The Ohio State University Comprehensive Cancer Center)

  • Tobey J. MacDonald

    (Pediatric Neuro-Oncology Program, Emory University School of Medicine)

  • Jan Koster

    (Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands)

  • Martin G. McCabe

    (School of Cancer and Enabling Sciences, University of Manchester, Manchester M20 4BX, UK)

  • Aaron L. Sarver

    (Masonic Cancer Center, University of Minnesota)

  • V. Peter Collins

    (University of Cambridge, Cambridge CB2 1QP, UK)

  • William A. Weiss

    (Pediatrics and Neurological Surgery, University of California)

  • David A. Largaespada

    (Masonic Cancer Center, University of Minnesota)

  • Lara S. Collier

    (School of Pharmacology, University of Wisconsin)

  • Michael D. Taylor

    (Arthur and Sonia Labatt Brain Tumour Research Center, and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G 1X8, Canada)

Abstract

In a mouse model and in human medulloblastoma patients, the metastases in an individual have similar genomic alterations and DNA methylation patterns, but these patterns are highly divergent from those of the primary tumour, indicating that therapies will need to be tailored to fit the molecular alterations present in the primary tumour and/or the metastases.

Suggested Citation

  • Xiaochong Wu & Paul A. Northcott & Adrian Dubuc & Adam J. Dupuy & David J. H. Shih & Hendrik Witt & Sidney Croul & Eric Bouffet & Daniel W. Fults & Charles G. Eberhart & Livia Garzia & Timothy Van Met, 2012. "Clonal selection drives genetic divergence of metastatic medulloblastoma," Nature, Nature, vol. 482(7386), pages 529-533, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10825
    DOI: 10.1038/nature10825
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    Cited by:

    1. Zhe Jiang & YoungJun Ju & Amjad Ali & Philip E. D. Chung & Patryk Skowron & Dong-Yu Wang & Mariusz Shrestha & Huiqin Li & Jeff C. Liu & Ioulia Vorobieva & Ronak Ghanbari-Azarnier & Ethel Mwewa & Maria, 2023. "Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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