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The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

Author

Listed:
  • Nan Liu

    (University of Pennsylvania
    Present addresses: Divison of Biological Sciences, Section of Neurobiology, Howard Hughes Medical Institute, University of California, San Diego, California 92093, USA (N.L.); Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden (M.L.).)

  • Michael Landreh

    (University of Pennsylvania
    Present addresses: Divison of Biological Sciences, Section of Neurobiology, Howard Hughes Medical Institute, University of California, San Diego, California 92093, USA (N.L.); Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden (M.L.).)

  • Kajia Cao

    (University of Pennsylvania
    Cell and Developmental Biology, University of Pennsylvania)

  • Masashi Abe

    (University of Pennsylvania)

  • Gert-Jan Hendriks

    (University of Pennsylvania)

  • Jason R. Kennerdell

    (University of Pennsylvania)

  • Yongqing Zhu

    (University of Pennsylvania)

  • Li-San Wang

    (University of Pennsylvania
    Institute on Aging, University of Pennsylvania
    Penn Center for Bioinformatics, University of Pennsylvania)

  • Nancy M. Bonini

    (University of Pennsylvania
    Howard Hughes Medical Institute, University of Pennsylvania)

Abstract

The conserved microRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.

Suggested Citation

  • Nan Liu & Michael Landreh & Kajia Cao & Masashi Abe & Gert-Jan Hendriks & Jason R. Kennerdell & Yongqing Zhu & Li-San Wang & Nancy M. Bonini, 2012. "The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila," Nature, Nature, vol. 482(7386), pages 519-523, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10810
    DOI: 10.1038/nature10810
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