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The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

Author

Listed:
  • Jing Huang

    (Howard Hughes Medical Institute, University of Michigan Medical School, 1150 West. Medical Center Drive
    University of Michigan Medical School, 1150 West. Medical Center Drive)

  • Buddha Gurung

    (Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine)

  • Bingbing Wan

    (Howard Hughes Medical Institute, University of Michigan Medical School, 1150 West. Medical Center Drive
    University of Michigan Medical School, 1150 West. Medical Center Drive)

  • Smita Matkar

    (Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine)

  • Natalia A. Veniaminova

    (University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA)

  • Ke Wan

    (Howard Hughes Medical Institute, University of Michigan Medical School, 1150 West. Medical Center Drive
    University of Michigan Medical School, 1150 West. Medical Center Drive)

  • Juanita L. Merchant

    (University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
    University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA)

  • Xianxin Hua

    (Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine)

  • Ming Lei

    (Howard Hughes Medical Institute, University of Michigan Medical School, 1150 West. Medical Center Drive
    University of Michigan Medical School, 1150 West. Medical Center Drive)

Abstract

Crystal structures of menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1–LEDGF heterodimer, show that menin contains a deep pocket that binds short peptides of MLL1 or JUND in the same manner, but produces opposite effects on transcription.

Suggested Citation

  • Jing Huang & Buddha Gurung & Bingbing Wan & Smita Matkar & Natalia A. Veniaminova & Ke Wan & Juanita L. Merchant & Xianxin Hua & Ming Lei, 2012. "The same pocket in menin binds both MLL and JUND but has opposite effects on transcription," Nature, Nature, vol. 482(7386), pages 542-546, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10806
    DOI: 10.1038/nature10806
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