IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v482y2012i7386d10.1038_nature10708.html
   My bibliography  Save this article

DCC constrains tumour progression via its dependence receptor activity

Author

Listed:
  • Marie Castets

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Laura Broutier

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Yann Molin

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Marie Brevet

    (Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot)

  • Guillaume Chazot

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Nicolas Gadot

    (Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot)

  • Armelle Paquet

    (Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot)

  • Laetitia Mazelin

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Loraine Jarrosson-Wuilleme

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Jean-Yves Scoazec

    (Endocrine Differentiation Laboratory, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon, Hospices Civils de Lyon, Hôpital Edouard Herriot)

  • Agnès Bernet

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Patrick Mehlen

    (Apoptosis, Cancer and Development Laboratory - Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

Abstract

A mouse model is developed in which the pro-apoptotic activity of DCC is silenced and the mice are more prone to intestinal tumour progression, giving insight into the role of DCC in human colorectal cancer.

Suggested Citation

  • Marie Castets & Laura Broutier & Yann Molin & Marie Brevet & Guillaume Chazot & Nicolas Gadot & Armelle Paquet & Laetitia Mazelin & Loraine Jarrosson-Wuilleme & Jean-Yves Scoazec & Agnès Bernet & Patr, 2012. "DCC constrains tumour progression via its dependence receptor activity," Nature, Nature, vol. 482(7386), pages 534-537, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10708
    DOI: 10.1038/nature10708
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10708
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10708?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Patrick N Harter & Jenny Zinke & Alexander Scholz & Julia Tichy & Cornelia Zachskorn & Hans M Kvasnicka & Benjamin Goeppert & Céline Delloye-Bourgeois & Elke Hattingen & Christian Senft & Joachim P St, 2014. "Netrin-1 Expression Is an Independent Prognostic Factor for Poor Patient Survival in Brain Metastases," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
    2. Céline Delloye-Bourgeois & Benjamin Gibert & Nicolas Rama & Jean-Guy Delcros & Nicolas Gadot & Jean-Yves Scoazec & Robert Krauss & Agnès Bernet & Patrick Mehlen, 2013. "Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity," PLOS Biology, Public Library of Science, vol. 11(8), pages 1-14, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:482:y:2012:i:7386:d:10.1038_nature10708. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.