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Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Author

Listed:
  • Steven Z. Josefowicz

    (Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University)

  • Rachel E. Niec

    (Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute)

  • Hye Young Kim

    (Children’s Hospital, Harvard Medical School)

  • Piper Treuting

    (and Histology and Imaging Core, School of Medicine, University of Washington)

  • Takatoshi Chinen

    (Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute
    Keio University School of Medicine, Tokyo 160-8582, Japan)

  • Ye Zheng

    (Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies)

  • Dale T. Umetsu

    (Children’s Hospital, Harvard Medical School)

  • Alexander Y. Rudensky

    (Howard Hughes Medical Institute and Immunology Program, Sloan Kettering Institute)

Abstract

Selective impairment of peripheral regulatory T-cell differentiation is found to result in spontaneous allergic TH2-type inflammation in the intestine and lungs, demonstrating the functional heterogeneity of regulatory T cells generated in the thymus and extrathymically in controlling immune mediated inflammation and disease.

Suggested Citation

  • Steven Z. Josefowicz & Rachel E. Niec & Hye Young Kim & Piper Treuting & Takatoshi Chinen & Ye Zheng & Dale T. Umetsu & Alexander Y. Rudensky, 2012. "Extrathymically generated regulatory T cells control mucosal TH2 inflammation," Nature, Nature, vol. 482(7385), pages 395-399, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7385:d:10.1038_nature10772
    DOI: 10.1038/nature10772
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    Cited by:

    1. Anna-Lena Geiselhöringer & Daphne Kolland & Arisha Johanna Patt & Linda Hammann & Amelie Köhler & Luisa Kreft & Nina Wichmann & Miriam Hils & Christiane Ruedl & Marc Riemann & Tilo Biedermann & David , 2024. "Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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