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The Drosophila melanogaster Genetic Reference Panel

Author

Listed:
  • Trudy F. C. Mackay

    (North Carolina State University)

  • Stephen Richards

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Eric A. Stone

    (North Carolina State University)

  • Antonio Barbadilla

    (Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain)

  • Julien F. Ayroles

    (North Carolina State University
    Present addresses: FAS Society of Fellows, Harvard University, 78 Mt Auburn Street, Cambridge, Massachusetts 02138, USA (J.F.A.) ; Functional Comparative Genomics Group, Institut de Biotecnologia i de Biomedicina - IBB, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain (S.C.); Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA (S.M.R.).)

  • Dianhui Zhu

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Sònia Casillas

    (Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
    Present addresses: FAS Society of Fellows, Harvard University, 78 Mt Auburn Street, Cambridge, Massachusetts 02138, USA (J.F.A.) ; Functional Comparative Genomics Group, Institut de Biotecnologia i de Biomedicina - IBB, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain (S.C.); Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA (S.M.R.).)

  • Yi Han

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Michael M. Magwire

    (North Carolina State University)

  • Julie M. Cridland

    (University of California - Irvine)

  • Mark F. Richardson

    (Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK)

  • Robert R. H. Anholt

    (North Carolina State University)

  • Maite Barrón

    (Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain)

  • Crystal Bess

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Kerstin Petra Blankenburg

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Mary Anna Carbone

    (North Carolina State University)

  • David Castellano

    (Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain)

  • Lesley Chaboub

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Laura Duncan

    (North Carolina State University)

  • Zeke Harris

    (North Carolina State University)

  • Mehwish Javaid

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Joy Christina Jayaseelan

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Shalini N. Jhangiani

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Katherine W. Jordan

    (North Carolina State University)

  • Fremiet Lara

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Faye Lawrence

    (North Carolina State University)

  • Sandra L. Lee

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Pablo Librado

    (Molecular Evolutionary Genetics Group, Faculty of Biology, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain)

  • Raquel S. Linheiro

    (Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK)

  • Richard F. Lyman

    (North Carolina State University)

  • Aaron J. Mackey

    (Center for Public Health Genomics, University of Virginia, PO Box 800717, Charlottesville, Virginia 22908, USA)

  • Mala Munidasa

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Donna Marie Muzny

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Lynne Nazareth

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Irene Newsham

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Lora Perales

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Ling-Ling Pu

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Carson Qu

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Miquel Ràmia

    (Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain)

  • Jeffrey G. Reid

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Stephanie M. Rollmann

    (North Carolina State University
    Present addresses: FAS Society of Fellows, Harvard University, 78 Mt Auburn Street, Cambridge, Massachusetts 02138, USA (J.F.A.) ; Functional Comparative Genomics Group, Institut de Biotecnologia i de Biomedicina - IBB, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain (S.C.); Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA (S.M.R.).)

  • Julio Rozas

    (Molecular Evolutionary Genetics Group, Faculty of Biology, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain)

  • Nehad Saada

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Lavanya Turlapati

    (North Carolina State University)

  • Kim C. Worley

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Yuan-Qing Wu

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Akihiko Yamamoto

    (North Carolina State University)

  • Yiming Zhu

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

  • Casey M. Bergman

    (Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK)

  • Kevin R. Thornton

    (University of California - Irvine)

  • David Mittelman

    (Virginia Tech)

  • Richard A. Gibbs

    (Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA)

Abstract

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of Drosophila genetics.

Suggested Citation

  • Trudy F. C. Mackay & Stephen Richards & Eric A. Stone & Antonio Barbadilla & Julien F. Ayroles & Dianhui Zhu & Sònia Casillas & Yi Han & Michael M. Magwire & Julie M. Cridland & Mark F. Richardson & R, 2012. "The Drosophila melanogaster Genetic Reference Panel," Nature, Nature, vol. 482(7384), pages 173-178, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7384:d:10.1038_nature10811
    DOI: 10.1038/nature10811
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