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Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK

Author

Listed:
  • Yu-yi Lin

    (Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    National Taiwan University Hospital, Taipei 100, Taiwan
    National Taiwan University Hospital, Taipei 100, Taiwan)

  • Samara Kiihl

    (Johns Hopkins Bloomberg, School of Public Health)

  • Yasir Suhail

    (Johns Hopkins University)

  • Shang-Yun Liu

    (Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan)

  • Yi-hsuan Chou

    (Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100, Taiwan)

  • Zheng Kuang

    (The Johns Hopkins University School of Medicine
    The High Throughput Biology Center, The Johns Hopkins University School of Medicine)

  • Jin-ying Lu

    (National Taiwan University Hospital, Taipei 100, Taiwan
    National Taiwan University Hospital, Taipei 100, Taiwan)

  • Chin Ni Khor

    (National RNAi Core Facility, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan)

  • Chi-Long Lin

    (National RNAi Core Facility, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan)

  • Joel S. Bader

    (Johns Hopkins University)

  • Rafael Irizarry

    (Johns Hopkins Bloomberg, School of Public Health)

  • Jef D. Boeke

    (The Johns Hopkins University School of Medicine
    The High Throughput Biology Center, The Johns Hopkins University School of Medicine)

Abstract

Genetic interaction profiles of human lysine deacetylases are generated by RNA interference knockdown to reveal the involvement of deacetylases in many critical biological processes, including metabolism, the cell cycle and development.

Suggested Citation

  • Yu-yi Lin & Samara Kiihl & Yasir Suhail & Shang-Yun Liu & Yi-hsuan Chou & Zheng Kuang & Jin-ying Lu & Chin Ni Khor & Chi-Long Lin & Joel S. Bader & Rafael Irizarry & Jef D. Boeke, 2012. "Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK," Nature, Nature, vol. 482(7384), pages 251-255, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7384:d:10.1038_nature10804
    DOI: 10.1038/nature10804
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