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High-throughput decoding of antitrypanosomal drug efficacy and resistance

Author

Listed:
  • Sam Alsford

    (London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK)

  • Sabine Eckert

    (The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Present address: Oxford Nanopore Technologies, 4 Robert Robinson Avenue, Oxford, OX4 4GA, UK.)

  • Nicola Baker

    (London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK)

  • Lucy Glover

    (London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK)

  • Alejandro Sanchez-Flores

    (The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK)

  • Ka Fai Leung

    (University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK)

  • Daniel J. Turner

    (The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Present address: Oxford Nanopore Technologies, 4 Robert Robinson Avenue, Oxford, OX4 4GA, UK.)

  • Mark C. Field

    (University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK)

  • Matthew Berriman

    (The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK)

  • David Horn

    (London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK)

Abstract

Five current human African trypanosomiasis drugs are used for genome-scale RNA interference target sequencing screens in Trypanosoma brucei, and reveal the transporters, organelles, enzymes and metabolic pathways that function to facilitate antitrypanosomal drug action.

Suggested Citation

  • Sam Alsford & Sabine Eckert & Nicola Baker & Lucy Glover & Alejandro Sanchez-Flores & Ka Fai Leung & Daniel J. Turner & Mark C. Field & Matthew Berriman & David Horn, 2012. "High-throughput decoding of antitrypanosomal drug efficacy and resistance," Nature, Nature, vol. 482(7384), pages 232-236, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7384:d:10.1038_nature10771
    DOI: 10.1038/nature10771
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    Cited by:

    1. Wanbiao Chen & Rongfeng Zou & Yi Mei & Jiawei Li & Yumi Xuan & Bing Cui & Junjie Zou & Juncheng Wang & Shaoquan Lin & Zhe Zhang & Chongyuan Wang, 2024. "Structural insights into drug transport by an aquaglyceroporin," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Aditi Mukherjee & Zakir Hossain & Esteban Erben & Shuai Ma & Jun Yong Choi & Hee-Sook Kim, 2023. "Identification of a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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