IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v482y2012i7383d10.1038_nature10729.html
   My bibliography  Save this article

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

Author

Listed:
  • Philipp Engel

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
    Present address: Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520-8106, USA.)

  • Arnaud Goepfert

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
    Core Program Structural Biology and Biophysics, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Frédéric V. Stanger

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
    Core Program Structural Biology and Biophysics, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Alexander Harms

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Alexander Schmidt

    (Proteomics Core Facility, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Tilman Schirmer

    (Core Program Structural Biology and Biophysics, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Christoph Dehio

    (Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

Abstract

FIC-domain-mediated adenylylation is controlled by inter- or intramolecular disturbance of the ATP binding site by an α-helix; such inhibition seems to be universal and conserved through evolution.

Suggested Citation

  • Philipp Engel & Arnaud Goepfert & Frédéric V. Stanger & Alexander Harms & Alexander Schmidt & Tilman Schirmer & Christoph Dehio, 2012. "Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins," Nature, Nature, vol. 482(7383), pages 107-110, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7383:d:10.1038_nature10729
    DOI: 10.1038/nature10729
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10729
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10729?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yongjin Wang & Yang Zhou & Chaowei Shi & Jiacong Liu & Guohua Lv & Huisi Huang & Shengrong Li & Liping Duan & Xinyi Zheng & Yue Liu & Haibo Zhou & Yonghua Wang & Zhengqiu Li & Ke Ding & Pinghua Sun & , 2022. "A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Dandan Wang & Lingfang Zhu & Xiangkai Zhen & Daoyan Yang & Changfu Li & Yating Chen & Huannan Wang & Yichen Qu & Xiaozhen Liu & Yanling Yin & Huawei Gu & Lei Xu & Chuanxing Wan & Yao Wang & Songying O, 2022. "A secreted effector with a dual role as a toxin and as a transcriptional factor," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:482:y:2012:i:7383:d:10.1038_nature10729. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.