IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v481y2012i7382d10.1038_nature10777.html
   My bibliography  Save this article

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Author

Listed:
  • Pontus Boström

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • Jun Wu

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • Mark P. Jedrychowski

    (Harvard Medical School)

  • Anisha Korde

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • Li Ye

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • James C. Lo

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • Kyle A. Rasbach

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • Elisabeth Almer Boström

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Jang Hyun Choi

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • Jonathan Z. Long

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

  • Shingo Kajimura

    (University of California)

  • Maria Cristina Zingaretti

    (Università Politecnica delle Marche, Electron Microscopy Unit-Azienda Ospedali Riuniti, Ancona 60020, Italy)

  • Birgitte F. Vind

    (Diabetes Research Center, Odense University Hospital, DK-5000, Odense, Denmark)

  • Hua Tu

    (LakePharma, Inc., 530 Harbor Blvd, Belmont, California 94002, USA)

  • Saverio Cinti

    (Università Politecnica delle Marche, Electron Microscopy Unit-Azienda Ospedali Riuniti, Ancona 60020, Italy)

  • Kurt Højlund

    (Diabetes Research Center, Odense University Hospital, DK-5000, Odense, Denmark)

  • Steven P. Gygi

    (Harvard Medical School)

  • Bruce M. Spiegelman

    (Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA)

Abstract

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.

Suggested Citation

  • Pontus Boström & Jun Wu & Mark P. Jedrychowski & Anisha Korde & Li Ye & James C. Lo & Kyle A. Rasbach & Elisabeth Almer Boström & Jang Hyun Choi & Jonathan Z. Long & Shingo Kajimura & Maria Cristina Z, 2012. "A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis," Nature, Nature, vol. 481(7382), pages 463-468, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7382:d:10.1038_nature10777
    DOI: 10.1038/nature10777
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10777
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10777?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Pedro L. Cosio & Manuel Crespo-Posadas & Álvaro Velarde-Sotres & Mireia Pelaez, 2021. "Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials," IJERPH, MDPI, vol. 18(5), pages 1-16, March.
    2. Zhijun Tan & Zengchun Ye & Jun Zhang & Yanru Chen & Cailian Cheng & Cheng Wang & Xun Liu & Tanqi Lou & Hui Peng, 2017. "Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
    3. Jiangshan Liu & Bote Qi & Lin Gan & Yanli Shen & Yu Zou, 2022. "A Bibliometric Analysis of the Literature on Irisin from 2012–2021," IJERPH, MDPI, vol. 19(10), pages 1-16, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:481:y:2012:i:7382:d:10.1038_nature10777. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.