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Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia

Author

Listed:
  • Duan-Sun Zhang

    (Harvard Medical School and Howard Hughes Medical Institute)

  • Valeria Piazza

    (Harvard Medical School and Howard Hughes Medical Institute
    Present address: Georg August University, D-37077 Göttingen, Germany.)

  • Benjamin J. Perrin

    (Molecular Biology and Biophysics, University of Minnesota)

  • Agnieszka K. Rzadzinska

    (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK)

  • J. Collin Poczatek

    (National Resource for Imaging Mass Spectrometry, Brigham and Women’s Hospital and Harvard Medical School)

  • Mei Wang

    (National Resource for Imaging Mass Spectrometry, Brigham and Women’s Hospital and Harvard Medical School)

  • Haydn M. Prosser

    (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK)

  • James M. Ervasti

    (Molecular Biology and Biophysics, University of Minnesota)

  • David P. Corey

    (Harvard Medical School and Howard Hughes Medical Institute)

  • Claude P. Lechene

    (National Resource for Imaging Mass Spectrometry, Brigham and Women’s Hospital and Harvard Medical School)

Abstract

Multi-isotope imaging mass spectrometry is used to quantify protein turnover in animal stereocilia, showing that rapid turnover occurs only in stereocilia tips.

Suggested Citation

  • Duan-Sun Zhang & Valeria Piazza & Benjamin J. Perrin & Agnieszka K. Rzadzinska & J. Collin Poczatek & Mei Wang & Haydn M. Prosser & James M. Ervasti & David P. Corey & Claude P. Lechene, 2012. "Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia," Nature, Nature, vol. 481(7382), pages 520-524, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7382:d:10.1038_nature10745
    DOI: 10.1038/nature10745
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    Cited by:

    1. Cristiane Santos & Amanda Cambraia & Shristi Shrestha & Melanie Cutler & Matthew Cottam & Guy Perkins & Varda Lev-Ram & Birbickram Roy & Christopher Acree & Keun-Young Kim & Thomas Deerinck & Danielle, 2024. "Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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