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The promise of induced pluripotent stem cells in research and therapy

Author

Listed:
  • Daisy A. Robinton

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute
    Brigham and Women's Hospital
    Harvard Medical School
    Broad Institute)

  • George Q. Daley

    (Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute
    Brigham and Women's Hospital
    Harvard Medical School
    Broad Institute)

Abstract

The field of stem-cell biology has been catapulted forward by the startling development of reprogramming technology. The ability to restore pluripotency to somatic cells through the ectopic co-expression of reprogramming factors has created powerful new opportunities for modelling human diseases and offers hope for personalized regenerative cell therapies. While the field is racing ahead, some researchers are pausing to evaluate whether induced pluripotent stem cells are indeed the true equivalents of embryonic stem cells and whether subtle differences between these types of cell might affect their research applications and therapeutic potential.

Suggested Citation

  • Daisy A. Robinton & George Q. Daley, 2012. "The promise of induced pluripotent stem cells in research and therapy," Nature, Nature, vol. 481(7381), pages 295-305, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7381:d:10.1038_nature10761
    DOI: 10.1038/nature10761
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    Cited by:

    1. Pengyi Yang & Xiaofeng Zheng & Vivek Jayaswal & Guang Hu & Jean Yee Hwa Yang & Raja Jothi, 2015. "Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data," PLOS Computational Biology, Public Library of Science, vol. 11(8), pages 1-18, August.

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