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Reductive carboxylation supports growth in tumour cells with defective mitochondria

Author

Listed:
  • Andrew R. Mullen

    (University of Texas – Southwestern Medical Center at Dallas)

  • William W. Wheaton

    (Northwestern University
    Northwestern University)

  • Eunsook S. Jin

    (University of Texas – Southwestern Medical Center at Dallas
    Advanced Imaging Research Center, University of Texas – Southwestern Medical Center at Dallas)

  • Pei-Hsuan Chen

    (University of Texas – Southwestern Medical Center at Dallas)

  • Lucas B. Sullivan

    (Northwestern University
    Northwestern University)

  • Tzuling Cheng

    (University of Texas – Southwestern Medical Center at Dallas)

  • Youfeng Yang

    (Urologic Oncology Branch, National Cancer Institute)

  • W. Marston Linehan

    (Urologic Oncology Branch, National Cancer Institute)

  • Navdeep S. Chandel

    (Northwestern University
    Northwestern University)

  • Ralph J. DeBerardinis

    (University of Texas – Southwestern Medical Center at Dallas
    McDermott Center for Human Growth and Development, University of Texas – Southwestern Medical Center at Dallas
    Harold C. Simmons Comprehensive Cancer Center, University of Texas – Southwestern Medical Center at Dallas)

Abstract

Tumour cells with defective mitochondria are found to use glutamine-dependent reductive carboxylation, rather than oxidative metabolism, as the major pathway of citrate and lipid formation.

Suggested Citation

  • Andrew R. Mullen & William W. Wheaton & Eunsook S. Jin & Pei-Hsuan Chen & Lucas B. Sullivan & Tzuling Cheng & Youfeng Yang & W. Marston Linehan & Navdeep S. Chandel & Ralph J. DeBerardinis, 2012. "Reductive carboxylation supports growth in tumour cells with defective mitochondria," Nature, Nature, vol. 481(7381), pages 385-388, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7381:d:10.1038_nature10642
    DOI: 10.1038/nature10642
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    Cited by:

    1. Nicole Kiweler & Catherine Delbrouck & Vitaly I. Pozdeev & Laura Neises & Leticia Soriano-Baguet & Kim Eiden & Feng Xian & Mohaned Benzarti & Lara Haase & Eric Koncina & Maryse Schmoetten & Christian , 2022. "Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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