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Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Author

Listed:
  • Hsien-Sung Huang

    (University of North Carolina School of Medicine)

  • John A. Allen

    (University of North Carolina School of Medicine)

  • Angela M. Mabb

    (University of North Carolina School of Medicine)

  • Ian F. King

    (University of North Carolina School of Medicine)

  • Jayalakshmi Miriyala

    (University of North Carolina School of Medicine)

  • Bonnie Taylor-Blake

    (University of North Carolina School of Medicine)

  • Noah Sciaky

    (University of North Carolina School of Medicine)

  • J. Walter Dutton

    (University of North Carolina School of Medicine)

  • Hyeong-Min Lee

    (University of North Carolina School of Medicine)

  • Xin Chen

    (Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina Eshelman School of Pharmacy)

  • Jian Jin

    (Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina Eshelman School of Pharmacy)

  • Arlene S. Bridges

    (University of North Carolina School of Medicine)

  • Mark J. Zylka

    (University of North Carolina School of Medicine
    Carolina Institute for Developmental Disabilities, University of North Carolina
    University of North Carolina Neuroscience Center)

  • Bryan L. Roth

    (University of North Carolina School of Medicine
    Carolina Institute for Developmental Disabilities, University of North Carolina
    University of North Carolina Neuroscience Center
    University of North Carolina Eshelman School of Pharmacy)

  • Benjamin D. Philpot

    (University of North Carolina School of Medicine
    Carolina Institute for Developmental Disabilities, University of North Carolina
    University of North Carolina Neuroscience Center)

Abstract

Cancer drugs that can potentially treat Angelman syndrome are identified.

Suggested Citation

  • Hsien-Sung Huang & John A. Allen & Angela M. Mabb & Ian F. King & Jayalakshmi Miriyala & Bonnie Taylor-Blake & Noah Sciaky & J. Walter Dutton & Hyeong-Min Lee & Xin Chen & Jian Jin & Arlene S. Bridges, 2012. "Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons," Nature, Nature, vol. 481(7380), pages 185-189, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7380:d:10.1038_nature10726
    DOI: 10.1038/nature10726
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