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Interactions between cancer stem cells and their niche govern metastatic colonization

Author

Listed:
  • Ilaria Malanchi

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

  • Albert Santamaria-Martínez

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

  • Evelyn Susanto

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

  • Hong Peng

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’
    Nanfang Hospital, Head and Neck Surgery, Southern Medical University)

  • Hans-Anton Lehr

    (University Institute of Pathology, CHUV, University of Lausanne)

  • Jean-Francois Delaloye

    (Centre Hospitalier Universitaire Vaudois)

  • Joerg Huelsken

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

Abstract

For the initiation of metastasis, there must be a small population of cancer stem cells at the secondary site and, to maintain this population and allow proliferation, infiltrating cancer cells must induce the expression of stromal periostin.

Suggested Citation

  • Ilaria Malanchi & Albert Santamaria-Martínez & Evelyn Susanto & Hong Peng & Hans-Anton Lehr & Jean-Francois Delaloye & Joerg Huelsken, 2012. "Interactions between cancer stem cells and their niche govern metastatic colonization," Nature, Nature, vol. 481(7379), pages 85-89, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7379:d:10.1038_nature10694
    DOI: 10.1038/nature10694
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    Cited by:

    1. Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. C. Megan Young & Laurent Beziaud & Pierre Dessen & Angela Madurga Alonso & Albert Santamaria-Martínez & Joerg Huelsken, 2023. "Metabolic dependencies of metastasis-initiating cells in female breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Kemwoue, Florent Feudjio & Deli, Vandi & Edima, Hélène Carole & Mendimi, Joseph Marie & Gninzanlong, Carlos Lawrence & Dedzo, Mireille Mbou & Tagne, Jules Fossi & Atangana, Jacques, 2022. "Effects of delay in a biological environment subject to tumor dynamics," Chaos, Solitons & Fractals, Elsevier, vol. 158(C).
    4. Chao-Hui Chang & Feng Liu & Stefania Militi & Svenja Hester & Reshma Nibhani & Siwei Deng & James Dunford & Aniko Rendek & Zahir Soonawalla & Roman Fischer & Udo Oppermann & Siim Pauklin, 2024. "The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-29, December.

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