IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v481y2012i7379d10.1038_nature10694.html
   My bibliography  Save this article

Interactions between cancer stem cells and their niche govern metastatic colonization

Author

Listed:
  • Ilaria Malanchi

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

  • Albert Santamaria-Martínez

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

  • Evelyn Susanto

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

  • Hong Peng

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’
    Nanfang Hospital, Head and Neck Surgery, Southern Medical University)

  • Hans-Anton Lehr

    (University Institute of Pathology, CHUV, University of Lausanne)

  • Jean-Francois Delaloye

    (Centre Hospitalier Universitaire Vaudois)

  • Joerg Huelsken

    (Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’)

Abstract

For the initiation of metastasis, there must be a small population of cancer stem cells at the secondary site and, to maintain this population and allow proliferation, infiltrating cancer cells must induce the expression of stromal periostin.

Suggested Citation

  • Ilaria Malanchi & Albert Santamaria-Martínez & Evelyn Susanto & Hong Peng & Hans-Anton Lehr & Jean-Francois Delaloye & Joerg Huelsken, 2012. "Interactions between cancer stem cells and their niche govern metastatic colonization," Nature, Nature, vol. 481(7379), pages 85-89, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7379:d:10.1038_nature10694
    DOI: 10.1038/nature10694
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10694
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10694?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Chao-Hui Chang & Feng Liu & Stefania Militi & Svenja Hester & Reshma Nibhani & Siwei Deng & James Dunford & Aniko Rendek & Zahir Soonawalla & Roman Fischer & Udo Oppermann & Siim Pauklin, 2024. "The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-29, December.
    3. C. Megan Young & Laurent Beziaud & Pierre Dessen & Angela Madurga Alonso & Albert Santamaria-Martínez & Joerg Huelsken, 2023. "Metabolic dependencies of metastasis-initiating cells in female breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Kemwoue, Florent Feudjio & Deli, Vandi & Edima, Hélène Carole & Mendimi, Joseph Marie & Gninzanlong, Carlos Lawrence & Dedzo, Mireille Mbou & Tagne, Jules Fossi & Atangana, Jacques, 2022. "Effects of delay in a biological environment subject to tumor dynamics," Chaos, Solitons & Fractals, Elsevier, vol. 158(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:481:y:2012:i:7379:d:10.1038_nature10694. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.