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Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Author

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  • Katja A. Lamia

    (Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Stephanie J. Papp

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ruth T. Yu

    (Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Grant D. Barish

    (Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • N. Henriette Uhlenhaut

    (Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Present addresses: Max-Delbrueck-Centrum Fuer Molekulare Medizin, Genetics and Physiology, Berlin, 13125, Germany (N.H.U.); Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, The Netherlands(J.W.J.).)

  • Johan W. Jonker

    (Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Present addresses: Max-Delbrueck-Centrum Fuer Molekulare Medizin, Genetics and Physiology, Berlin, 13125, Germany (N.H.U.); Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, The Netherlands(J.W.J.).)

  • Michael Downes

    (Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ronald M. Evans

    (Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

Abstract

Circadian co-regulators cryptochrome 1 and 2 are shown to alter globally the transcriptional response to glucocorticoids in mouse embryonic fibroblasts.

Suggested Citation

  • Katja A. Lamia & Stephanie J. Papp & Ruth T. Yu & Grant D. Barish & N. Henriette Uhlenhaut & Johan W. Jonker & Michael Downes & Ronald M. Evans, 2011. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor," Nature, Nature, vol. 480(7378), pages 552-556, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10700
    DOI: 10.1038/nature10700
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    Cited by:

    1. Federica Catalano & Francesca De Vito & Velia Cassano & Teresa Vanessa Fiorentino & Angela Sciacqua & Marta Letizia Hribal, 2022. "Circadian Clock Desynchronization and Insulin Resistance," IJERPH, MDPI, vol. 20(1), pages 1-11, December.

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