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Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease

Author

Listed:
  • Philipp Koch

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Peter Breuer

    (University of Bonn Medical Center, 53105 Bonn, Germany)

  • Michael Peitz

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Johannes Jungverdorben

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Jaideep Kesavan

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Daniel Poppe

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Jonas Doerr

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Julia Ladewig

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Jerome Mertens

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

  • Thomas Tüting

    (University of Bonn Medical Center, 53127 Bonn, Germany)

  • Per Hoffmann

    (Life and Brain Center, University of Bonn, 53127 Bonn, Germany)

  • Thomas Klockgether

    (University of Bonn Medical Center, 53105 Bonn, Germany
    DZNE, German Center for Neurodegenerative Diseases, 53175 Bonn, Germany)

  • Bernd O. Evert

    (University of Bonn Medical Center, 53105 Bonn, Germany)

  • Ullrich Wüllner

    (University of Bonn Medical Center, 53105 Bonn, Germany)

  • Oliver Brüstle

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation)

Abstract

Human neurons derived from induced pluripotent stem cells permit the study of aberrant protein processing and aggregation in Machado–Joseph disease.

Suggested Citation

  • Philipp Koch & Peter Breuer & Michael Peitz & Johannes Jungverdorben & Jaideep Kesavan & Daniel Poppe & Jonas Doerr & Julia Ladewig & Jerome Mertens & Thomas Tüting & Per Hoffmann & Thomas Klockgether, 2011. "Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease," Nature, Nature, vol. 480(7378), pages 543-546, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10671
    DOI: 10.1038/nature10671
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    Cited by:

    1. Patricia R. Pitrez & Luis M. Monteiro & Oliver Borgogno & Xavier Nissan & Jerome Mertens & Lino Ferreira, 2024. "Cellular reprogramming as a tool to model human aging in a dish," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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