IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v480y2011i7378d10.1038_nature10606.html
   My bibliography  Save this article

Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum

Author

Listed:
  • Cécile Crosnier

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton)

  • Leyla Y. Bustamante

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

  • S. Josefin Bartholdson

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton)

  • Amy K. Bei

    (Harvard School of Public Health)

  • Michel Theron

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

  • Makoto Uchikawa

    (Tokyo Red Cross Blood Center)

  • Souleymane Mboup

    (Laboratory of Bacteriology and Virology, Le Dantec Hospital and Laboratory of Parasitology, Cheikh Anta Diop University, BP: 7325)

  • Omar Ndir

    (Laboratory of Bacteriology and Virology, Le Dantec Hospital and Laboratory of Parasitology, Cheikh Anta Diop University, BP: 7325)

  • Dominic P. Kwiatkowski

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton
    Wellcome Trust Centre for Human Genetics)

  • Manoj T. Duraisingh

    (Harvard School of Public Health)

  • Julian C. Rayner

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

  • Gavin J. Wright

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton
    Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

Abstract

No entry for malaria parasites The ability to prevent or impair the invasion of erythrocytes by the Plasmodium falciparum merozoite, the initial blood stage of malaria infection, has long been an ambition for those working on antimalarial therapeutics. It has proved elusive, but comes a step closer with the identification of a specific interaction between the parasite ligand PfRh5 and the erythrocyte receptor basigin, which is essential for parasite invasion of erythrocytes. Invasion can be inhibited by anti-basigin antibodies in all laboratory-adapted and field strains of P. falciparum tested, providing a promising starting point for the development of invasion-blocking drugs and vaccines.

Suggested Citation

  • Cécile Crosnier & Leyla Y. Bustamante & S. Josefin Bartholdson & Amy K. Bei & Michel Theron & Makoto Uchikawa & Souleymane Mboup & Omar Ndir & Dominic P. Kwiatkowski & Manoj T. Duraisingh & Julian C. , 2011. "Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum," Nature, Nature, vol. 480(7378), pages 534-537, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10606
    DOI: 10.1038/nature10606
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10606
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10606?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Prasun Kundu & Deboki Naskar & Shannon J. McKie & Sheena Dass & Usheer Kanjee & Viola Introini & Marcelo U. Ferreira & Pietro Cicuta & Manoj Duraisingh & Janet E. Deane & Julian C. Rayner, 2023. "The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Tony Triglia & Stephen W. Scally & Benjamin A. Seager & Michał Pasternak & Laura F. Dagley & Alan F. Cowman, 2023. "Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Barnabas G. Williams & Lloyd D. W. King & David Pulido & Doris Quinkert & Amelia M. Lias & Sarah E. Silk & Robert J. Ragotte & Hannah Davies & Jordan R. Barrett & Kirsty McHugh & Cassandra A. Rigby & , 2024. "Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10606. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.