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Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum

Author

Listed:
  • Cécile Crosnier

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton)

  • Leyla Y. Bustamante

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

  • S. Josefin Bartholdson

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton)

  • Amy K. Bei

    (Harvard School of Public Health)

  • Michel Theron

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

  • Makoto Uchikawa

    (Tokyo Red Cross Blood Center)

  • Souleymane Mboup

    (Laboratory of Bacteriology and Virology, Le Dantec Hospital and Laboratory of Parasitology, Cheikh Anta Diop University, BP: 7325)

  • Omar Ndir

    (Laboratory of Bacteriology and Virology, Le Dantec Hospital and Laboratory of Parasitology, Cheikh Anta Diop University, BP: 7325)

  • Dominic P. Kwiatkowski

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton
    Wellcome Trust Centre for Human Genetics)

  • Manoj T. Duraisingh

    (Harvard School of Public Health)

  • Julian C. Rayner

    (Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

  • Gavin J. Wright

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton
    Malaria Programme, Wellcome Trust Sanger Institute, Hinxton)

Abstract

No entry for malaria parasites The ability to prevent or impair the invasion of erythrocytes by the Plasmodium falciparum merozoite, the initial blood stage of malaria infection, has long been an ambition for those working on antimalarial therapeutics. It has proved elusive, but comes a step closer with the identification of a specific interaction between the parasite ligand PfRh5 and the erythrocyte receptor basigin, which is essential for parasite invasion of erythrocytes. Invasion can be inhibited by anti-basigin antibodies in all laboratory-adapted and field strains of P. falciparum tested, providing a promising starting point for the development of invasion-blocking drugs and vaccines.

Suggested Citation

  • Cécile Crosnier & Leyla Y. Bustamante & S. Josefin Bartholdson & Amy K. Bei & Michel Theron & Makoto Uchikawa & Souleymane Mboup & Omar Ndir & Dominic P. Kwiatkowski & Manoj T. Duraisingh & Julian C. , 2011. "Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum," Nature, Nature, vol. 480(7378), pages 534-537, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7378:d:10.1038_nature10606
    DOI: 10.1038/nature10606
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    Cited by:

    1. Prasun Kundu & Deboki Naskar & Shannon J. McKie & Sheena Dass & Usheer Kanjee & Viola Introini & Marcelo U. Ferreira & Pietro Cicuta & Manoj Duraisingh & Janet E. Deane & Julian C. Rayner, 2023. "The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Jaishree Tripathi & Lei Zhu & Sourav Nayak & Michal Stoklasa & Zbynek Bozdech, 2022. "Stochastic expression of invasion genes in Plasmodium falciparum schizonts," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Tony Triglia & Stephen W. Scally & Benjamin A. Seager & Michał Pasternak & Laura F. Dagley & Alan F. Cowman, 2023. "Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Barnabas G. Williams & Lloyd D. W. King & David Pulido & Doris Quinkert & Amelia M. Lias & Sarah E. Silk & Robert J. Ragotte & Hannah Davies & Jordan R. Barrett & Kirsty McHugh & Cassandra A. Rigby & , 2024. "Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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