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Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB

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  • Vincent J. Lynch

    (Yale University)

  • Gemma May

    (Yale University)

  • Günter P. Wagner

    (Yale University)

Abstract

Evolution of gene regulation Changes in cis-regulatory regions of the genome play an important part in the evolution of gene regulation. Lynch et al. explore the influence of amino acid substitutions in transcription factors on gene regulation. They show how, over evolutionary time, amino acid substitutions in the transcription factor CEBPB in the stem-lineage of placental mammals reorganize the location of key phosphorylation sites, thereby changing the way it responds to cAMP/PKA signalling.

Suggested Citation

  • Vincent J. Lynch & Gemma May & Günter P. Wagner, 2011. "Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB," Nature, Nature, vol. 480(7377), pages 383-386, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7377:d:10.1038_nature10595
    DOI: 10.1038/nature10595
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    Cited by:

    1. Gross, Eitan, 2015. "Effect of environmental stress on regulation of gene expression in the yeast," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 430(C), pages 224-235.

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