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Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

Author

Listed:
  • Fang Sun

    (F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School)

  • Kevin K. Park

    (Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami)

  • Stephane Belin

    (F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School)

  • Dongqing Wang

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Tao Lu

    (Harvard Medical School)

  • Gang Chen

    (F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School)

  • Kang Zhang

    (Shiley Eye Center, University of California at San Diego)

  • Cecil Yeung

    (F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School)

  • Guoping Feng

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Bruce A. Yankner

    (Harvard Medical School)

  • Zhigang He

    (F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School)

Abstract

Nerve regeneration at a distance Long-range extensive repair following nerve damage has been demonstrated in the peripheral nervous system, but such robust regeneration is rare in the central nervous system. Previous studies have observed some repair following molecular manipulations of the regeneration signalling pathways, but these gains often tapered off after two weeks. Zhigang He and colleagues identify a modification to two signalling pathways that promotes enhanced axonal regeneration following a nerve crush injury. These manipulated pathways act in synergy to promote the expression of growth-related genes that maintain high enough levels to sustain long-range regenerative growth.

Suggested Citation

  • Fang Sun & Kevin K. Park & Stephane Belin & Dongqing Wang & Tao Lu & Gang Chen & Kang Zhang & Cecil Yeung & Guoping Feng & Bruce A. Yankner & Zhigang He, 2011. "Sustained axon regeneration induced by co-deletion of PTEN and SOCS3," Nature, Nature, vol. 480(7377), pages 372-375, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7377:d:10.1038_nature10594
    DOI: 10.1038/nature10594
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    Cited by:

    1. Kun Rhee & Yanjie Wang & Johanna ten Hoeve & Linsey Stiles & Thao Thi Thu Nguyen & Xiangmei Zhang & Laurent Vergnes & Karen Reue & Orian Shirihai & Dean Bok & Xian-Jie Yang, 2022. "Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Valentina Cigliola & Adam Shoffner & Nutishia Lee & Jianhong Ou & Trevor J. Gonzalez & Jiaul Hoque & Clayton J. Becker & Yanchao Han & Grace Shen & Timothy D. Faw & Muhammad M. Abd-El-Barr & Shyni Var, 2023. "Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Noemie Vilallongue & Julia Schaeffer & Anne-Marie Hesse & Céline Delpech & Béatrice Blot & Antoine Paccard & Elise Plissonnier & Blandine Excoffier & Yohann Couté & Stephane Belin & Homaira Nawabi, 2022. "Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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