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Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

Author

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  • Filippo M. Cernilogar

    (Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64
    Dulbecco Telethon Institute, IGB ABT-CNR, Via Pietro Castellino 111
    Present address: Helmholtz Center Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Munich-Neuherberg, Germany.)

  • Maria Cristina Onorati

    (Dulbecco Telethon Institute at Università degli Studi di Palermo, Sezione Biologia Cellulare, Viale delle Scienze, Edificio 16)

  • Greg O. Kothe

    (Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park)

  • A. Maxwell Burroughs

    (RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama)

  • Krishna Mohan Parsi

    (Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64
    Dulbecco Telethon Institute, IGB ABT-CNR, Via Pietro Castellino 111)

  • Achim Breiling

    (DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 580)

  • Federica Lo Sardo

    (Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64)

  • Alka Saxena

    (RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama)

  • Keita Miyoshi

    (Keio University School of Medicine)

  • Haruhiko Siomi

    (Keio University School of Medicine)

  • Mikiko C. Siomi

    (Keio University School of Medicine
    JST, CREST)

  • Piero Carninci

    (RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama)

  • David S. Gilmour

    (Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park)

  • Davide F. V. Corona

    (Dulbecco Telethon Institute at Università degli Studi di Palermo, Sezione Biologia Cellulare, Viale delle Scienze, Edificio 16)

  • Valerio Orlando

    (Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64)

Abstract

Nuclear role for RNAi RNA interference (RNAi) is generally associated with post-transcriptional gene silencing, but there is growing evidence that small RNAs and RNAi components also have a role in transcriptional gene silencing in the nucleus. This study shows that, in Drosophila, the RNAi components Dicer-2 (Dcr2) and Argonaute-2 (AGO2) are present in the nucleus, associating with transcriptionally active gene loci and interacting with RNA polymerase II. Dcr2 and AGO2 are associated with sense and antisense transcripts and seem to have a role in regulating transcription, particularly during heatshock.

Suggested Citation

  • Filippo M. Cernilogar & Maria Cristina Onorati & Greg O. Kothe & A. Maxwell Burroughs & Krishna Mohan Parsi & Achim Breiling & Federica Lo Sardo & Alka Saxena & Keita Miyoshi & Haruhiko Siomi & Mikiko, 2011. "Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila," Nature, Nature, vol. 480(7377), pages 391-395, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7377:d:10.1038_nature10492
    DOI: 10.1038/nature10492
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    Cited by:

    1. Shengzhang Dong & George Dimopoulos, 2023. "Aedes aegypti Argonaute 2 controls arbovirus infection and host mortality," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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