IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v480y2011i7376d10.1038_nature10672.html
   My bibliography  Save this article

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

Author

Listed:
  • Michael Reuter

    (European Molecular Biology Laboratory, 6 Rue Jules Horowitz, BP 181, 38042 Grenoble, France
    CNRS-UJF-EMBL International Unit (UMI 3265) for Virus Host Cell Interactions (UVHCI), 38042 Grenoble, France)

  • Philipp Berninger

    (European Molecular Biology Laboratory, 6 Rue Jules Horowitz, BP 181, 38042 Grenoble, France
    CNRS-UJF-EMBL International Unit (UMI 3265) for Virus Host Cell Interactions (UVHCI), 38042 Grenoble, France)

  • Shinichiro Chuma

    (Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
    Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 606-8501, Japan)

  • Hardik Shah

    (Mount Sinai School of Medicine)

  • Mihoko Hosokawa

    (Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
    Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 606-8501, Japan)

  • Charlotta Funaya

    (European Molecular Biology Laboratory, EMBL Meyerhof Str. 1, 69117 Heidelberg, Germany)

  • Claude Antony

    (European Molecular Biology Laboratory, EMBL Meyerhof Str. 1, 69117 Heidelberg, Germany)

  • Ravi Sachidanandam

    (Mount Sinai School of Medicine)

  • Ramesh S. Pillai

    (European Molecular Biology Laboratory, 6 Rue Jules Horowitz, BP 181, 38042 Grenoble, France
    CNRS-UJF-EMBL International Unit (UMI 3265) for Virus Host Cell Interactions (UVHCI), 38042 Grenoble, France)

Abstract

Piwi protein Miwi is shown to be a small RNA-guided RNase in mice; disrupting the catalytic activity of Miwi results in increased accumulation of LINE1 retrotransposon transcripts and male infertility.

Suggested Citation

  • Michael Reuter & Philipp Berninger & Shinichiro Chuma & Hardik Shah & Mihoko Hosokawa & Charlotta Funaya & Claude Antony & Ravi Sachidanandam & Ramesh S. Pillai, 2011. "Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing," Nature, Nature, vol. 480(7376), pages 264-267, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7376:d:10.1038_nature10672
    DOI: 10.1038/nature10672
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10672
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10672?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Birgit Stallmeyer & Clara Bühlmann & Rytis Stakaitis & Ann-Kristin Dicke & Farah Ghieh & Luisa Meier & Ansgar Zoch & David MacKenzie MacLeod & Johanna Steingröver & Özlem Okutman & Daniela Fietz & Adr, 2024. "Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:480:y:2011:i:7376:d:10.1038_nature10672. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.