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Predicting mutation outcome from early stochastic variation in genetic interaction partners

Author

Listed:
  • Alejandro Burga

    (EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF))

  • M. Olivia Casanueva

    (EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF))

  • Ben Lehner

    (EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF)
    Institució Catalana de Recerca i Estudis Avançats, Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF))

Abstract

Mutations sometimes only affect a subset of genetically identical individuals; here, variation in the expression of chaperones and gene duplicates is shown to predict mutation outcome in C. elegans.

Suggested Citation

  • Alejandro Burga & M. Olivia Casanueva & Ben Lehner, 2011. "Predicting mutation outcome from early stochastic variation in genetic interaction partners," Nature, Nature, vol. 480(7376), pages 250-253, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7376:d:10.1038_nature10665
    DOI: 10.1038/nature10665
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    Cited by:

    1. Bryan Sands & Soo Yun & Alexander R. Mendenhall, 2021. "Introns control stochastic allele expression bias," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Kemal Keseroglu & Oriana Q. H. Zinani & Sevdenur Keskin & Hannah Seawall & Eslim E. Alpay & Ertuğrul M. Özbudak, 2023. "Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Kaushik Bhattacharya & Samarpan Maiti & Szabolcs Zahoran & Lorenz Weidenauer & Dina Hany & Diana Wider & Lilia Bernasconi & Manfredo Quadroni & Martine Collart & Didier Picard, 2022. "Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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