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A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

Author

Listed:
  • Satoru Yokoyama

    (Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School)

  • Susan L. Woods

    (Queensland Institute of Medical Research)

  • Glen M. Boyle

    (Queensland Institute of Medical Research)

  • Lauren G. Aoude

    (Queensland Institute of Medical Research)

  • Stuart MacGregor

    (Queensland Institute of Medical Research)

  • Victoria Zismann

    (Translational Genomics Research Institute)

  • Michael Gartside

    (Queensland Institute of Medical Research)

  • Anne E. Cust

    (Cancer Epidemiology and Services Research, Sydney School of Public Health, Sydney Medical School, The University of Sydney)

  • Rizwan Haq

    (Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School)

  • Mark Harland

    (Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James’s University Hospital)

  • John C. Taylor

    (Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James’s University Hospital)

  • David L. Duffy

    (Queensland Institute of Medical Research)

  • Kelly Holohan

    (Queensland Institute of Medical Research)

  • Ken Dutton-Regester

    (Queensland Institute of Medical Research)

  • Jane M. Palmer

    (Queensland Institute of Medical Research)

  • Vanessa Bonazzi

    (Queensland Institute of Medical Research)

  • Mitchell S. Stark

    (Queensland Institute of Medical Research)

  • Judith Symmons

    (Queensland Institute of Medical Research)

  • Matthew H. Law

    (Queensland Institute of Medical Research)

  • Christopher Schmidt

    (Queensland Institute of Medical Research)

  • Cathy Lanagan

    (Queensland Institute of Medical Research)

  • Linda O’Connor

    (Queensland Institute of Medical Research)

  • Elizabeth A. Holland

    (Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia)

  • Helen Schmid

    (Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia)

  • Judith A. Maskiell

    (Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne)

  • Jodie Jetann

    (Viertel Centre for Research in Cancer Control, The Cancer Council Queensland)

  • Megan Ferguson

    (Viertel Centre for Research in Cancer Control, The Cancer Council Queensland)

  • Mark A. Jenkins

    (Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne)

  • Richard F. Kefford

    (Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia)

  • Graham G. Giles

    (Cancer Epidemiology Centre, The Cancer Council Victoria)

  • Bruce K. Armstrong

    (Cancer Epidemiology and Services Research, Sydney School of Public Health, Sydney Medical School, The University of Sydney)

  • Joanne F. Aitken

    (Viertel Centre for Research in Cancer Control, The Cancer Council Queensland)

  • John L. Hopper

    (Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne)

  • David C. Whiteman

    (Queensland Institute of Medical Research)

  • Paul D. Pharoah

    (University of Cambridge, Cambridge CB1 8RN)

  • Douglas F. Easton

    (University of Cambridge, Cambridge CB1 8RN)

  • Alison M. Dunning

    (University of Cambridge, Cambridge CB1 8RN)

  • Julia A. Newton-Bishop

    (Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James’s University Hospital)

  • Grant W. Montgomery

    (Queensland Institute of Medical Research)

  • Nicholas G. Martin

    (Queensland Institute of Medical Research)

  • Graham J. Mann

    (Westmead Institute of Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia)

  • D. Timothy Bishop

    (Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James’s University Hospital)

  • Hensin Tsao

    (Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School)

  • Jeffrey M. Trent

    (Translational Genomics Research Institute)

  • David E. Fisher

    (Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School)

  • Nicholas K. Hayward

    (Queensland Institute of Medical Research)

  • Kevin M. Brown

    (Translational Genomics Research Institute
    National Cancer Institute, National Institutes of Health)

Abstract

Whole-genome sequencing identifies a novel germline variant in the oncogene MITF, which is associated with the development of melanoma.

Suggested Citation

  • Satoru Yokoyama & Susan L. Woods & Glen M. Boyle & Lauren G. Aoude & Stuart MacGregor & Victoria Zismann & Michael Gartside & Anne E. Cust & Rizwan Haq & Mark Harland & John C. Taylor & David L. Duffy, 2011. "A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma," Nature, Nature, vol. 480(7375), pages 99-103, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10630
    DOI: 10.1038/nature10630
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    Cited by:

    1. Fang Liang & Yu Zhang & Lin Li & Yexin Yang & Ji-Feng Fei & Yanmei Liu & Wei Qin, 2022. "SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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