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Control of Drosophila endocycles by E2F and CRL4CDT2

Author

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  • Norman Zielke

    (German Cancer Research Center (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA)

  • Kerry J. Kim

    (Center for Cell Dynamics, Friday Harbor Labs, University of Washington, 620 University Road)

  • Vuong Tran

    (Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA)

  • Shusaku T. Shibutani

    (University of North Carolina)

  • Maria-Jose Bravo

    (Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA)

  • Sabarish Nagarajan

    (Clark H. Smith Brain Tumor Center, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada
    University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada)

  • Monique van Straaten

    (German Cancer Research Center (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Brigitte Woods

    (Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA)

  • George von Dassow

    (Center for Cell Dynamics, Friday Harbor Labs, University of Washington, 620 University Road)

  • Carmen Rottig

    (Institute of Molecular and Life Sciences (IMLS), Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland)

  • Christian F. Lehner

    (Institute of Molecular and Life Sciences (IMLS), Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland)

  • Savraj S. Grewal

    (Clark H. Smith Brain Tumor Center, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada
    University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada)

  • Robert J. Duronio

    (University of North Carolina)

  • Bruce A. Edgar

    (German Cancer Research Center (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA)

Abstract

Pyruvate kinase in tumour cells Pyruvate kinase M2 (PKM2) is a key enzyme in glycolysis that is highly expressed in cancer. Here, Zhimin Lu and colleagues show that PKM2 can translocate to the nucleus in response to epidermal growth factor, where it contributes to β-catenin-dependent gene activation. This non-metabolic function of PKM2 seems to be important for tumour cell proliferation.

Suggested Citation

  • Norman Zielke & Kerry J. Kim & Vuong Tran & Shusaku T. Shibutani & Maria-Jose Bravo & Sabarish Nagarajan & Monique van Straaten & Brigitte Woods & George von Dassow & Carmen Rottig & Christian F. Lehn, 2011. "Control of Drosophila endocycles by E2F and CRL4CDT2," Nature, Nature, vol. 480(7375), pages 123-127, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10579
    DOI: 10.1038/nature10579
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    Cited by:

    1. Xingting Guo & Chenhui Wang & Yongchao Zhang & Ruxue Wei & Rongwen Xi, 2024. "Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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