IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v480y2011i7375d10.1038_nature10560.html
   My bibliography  Save this article

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

Author

Listed:
  • Mardo Kõivomägi

    (Institute of Technology, University of Tartu)

  • Ervin Valk

    (Institute of Technology, University of Tartu)

  • Rainis Venta

    (Institute of Technology, University of Tartu)

  • Anna Iofik

    (Institute of Technology, University of Tartu)

  • Martin Lepiku

    (Institute of Technology, University of Tartu)

  • Eva Rose M. Balog

    (University of California)

  • Seth M. Rubin

    (University of California)

  • David O. Morgan

    (University of California)

  • Mart Loog

    (Institute of Technology, University of Tartu)

Abstract

Proteins as complex switches Multisite phosphorylation of a protein can allow an ultra-sensitive switch-like response. For example, in the yeast cyclin-dependent kinase (Cdk) inhibitor Sic1, it can lead to its rapid destruction and the initiation of S-phase of the cell cycle. Kõivomägi et al. demonstrate that multisite phosphorylations of Sic1 are not random events, but are part of a specific phosphorylation cascade catalysed by two different Cdk–cyclin complexes, with initial priming phosphorylations followed by docking-dependent phosphorylation events. Such an intricate mechanism may also apply to other kinase targets with multiple phosphorylation sites.

Suggested Citation

  • Mardo Kõivomägi & Ervin Valk & Rainis Venta & Anna Iofik & Martin Lepiku & Eva Rose M. Balog & Seth M. Rubin & David O. Morgan & Mart Loog, 2011. "Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase," Nature, Nature, vol. 480(7375), pages 128-131, December.
  • Handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10560
    DOI: 10.1038/nature10560
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10560
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature10560?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alex N Nguyen Ba & Bob Strome & Jun Jie Hua & Jonathan Desmond & Isabelle Gagnon-Arsenault & Eric L Weiss & Christian R Landry & Alan M Moses, 2014. "Detecting Functional Divergence after Gene Duplication through Evolutionary Changes in Posttranslational Regulatory Sequences," PLOS Computational Biology, Public Library of Science, vol. 10(12), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10560. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.