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Membrane protein sequestering by ionic protein–lipid interactions

Author

Listed:
  • Geert van den Bogaart

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

  • Karsten Meyenberg

    (Institute for Organic and Biomolecular Chemistry, Georg-August-University Göttingen, Tammannstraße 2)

  • H. Jelger Risselada

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

  • Hayder Amin

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

  • Katrin I. Willig

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

  • Barbara E. Hubrich

    (Institute for Organic and Biomolecular Chemistry, Georg-August-University Göttingen, Tammannstraße 2)

  • Markus Dier

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

  • Stefan W. Hell

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

  • Helmut Grubmüller

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

  • Ulf Diederichsen

    (Institute for Organic and Biomolecular Chemistry, Georg-August-University Göttingen, Tammannstraße 2)

  • Reinhard Jahn

    (Max Planck Institute for Biophysical Chemistry, Am Faßberg 11)

Abstract

Electrostatic factors in membrane organization Exocytosis in neuronal cells requires the SNARE protein syntaxin-1A, which is clustered at sites where synaptic vesicles are poised to undergo exocytosis. Reinhard Jahn and colleagues use super-resolution stimulated-emission depletion (STED) microscopy to show that syntaxin clusters in the membrane through electrostatic interactions with the strongly anionic lipid phosphatidylinositol-4,5-bisphosphate (PIP2) into 70-nanometre microdomains. The results demonstrate that electrostatic protein–lipid interactions can result in the formation of microdomains independent of cholesterol or lipid phases and have important implications for the organization of the plasma membrane.

Suggested Citation

  • Geert van den Bogaart & Karsten Meyenberg & H. Jelger Risselada & Hayder Amin & Katrin I. Willig & Barbara E. Hubrich & Markus Dier & Stefan W. Hell & Helmut Grubmüller & Ulf Diederichsen & Reinhard J, 2011. "Membrane protein sequestering by ionic protein–lipid interactions," Nature, Nature, vol. 479(7374), pages 552-555, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7374:d:10.1038_nature10545
    DOI: 10.1038/nature10545
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    Cited by:

    1. Heidi Koldsø & David Shorthouse & Jean Hélie & Mark S P Sansom, 2014. "Lipid Clustering Correlates with Membrane Curvature as Revealed by Molecular Simulations of Complex Lipid Bilayers," PLOS Computational Biology, Public Library of Science, vol. 10(10), pages 1-11, October.

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