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Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

Author

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  • Christine Moussion

    (CNRS, Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne
    Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie Structurale)

  • Jean-Philippe Girard

    (CNRS, Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne
    Université de Toulouse, UPS, Institut de Pharmacologie et de Biologie Structurale)

Abstract

Dendritic cells in immune surveillance Christine Moussion and Jean-Philippe Girard report that dendritic cells in the immune system have an unexpected immune surveillance role in lymphocyte recirculation during homeostasis. Lymphotoxin ligands derived from dendritic cells promote the growth of high endothelial venules — blood vessels specialized in lymphocyte recruitment — which control the entry of naive lymphocytes from the blood into lymph nodes.

Suggested Citation

  • Christine Moussion & Jean-Philippe Girard, 2011. "Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules," Nature, Nature, vol. 479(7374), pages 542-546, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7374:d:10.1038_nature10540
    DOI: 10.1038/nature10540
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    Cited by:

    1. Vitaly V Ganusov & Jeremy Auerbach, 2014. "Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism," PLOS Computational Biology, Public Library of Science, vol. 10(5), pages 1-15, May.

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