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Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants

Author

Listed:
  • Daniel J. Gibbs

    (School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham)

  • Seung Cho Lee

    (University of California)

  • Nurulhikma Md Isa

    (School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham)

  • Silvia Gramuglia

    (School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham)

  • Takeshi Fukao

    (University of California)

  • George W. Bassel

    (School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham)

  • Cristina Sousa Correia

    (School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham)

  • Françoise Corbineau

    (UPMC Univ Paris 06, UR5-EAC 7180 CNRS, Boîte courrier 156, 4 place Jussieu)

  • Frederica L. Theodoulou

    (Rothamsted Research)

  • Julia Bailey-Serres

    (University of California)

  • Michael J. Holdsworth

    (School of Biosciences and Centre for Plant Integrative Biology, University of Nottingham)

Abstract

How plants sense oxygen shortage Tolerance of plants to flooding is an important factor for food security, particularly in the developing world. When plants are submerged in water they experience hypoxia, which triggers changes in gene transcription that promote anaerobic metabolism and sustain ATP production. Two complementary studies identify the mechanism that senses reduced oxygen levels in Arabidopsis. They report that the N-end rule pathway of targeted proteolysis regulates the stability of key hypoxia-response transcription factors. Enhanced stability of these proteins under low oxygen conditions improves plant survival, suggesting a target for possible genetic improvement of flooding-tolerance in crops.

Suggested Citation

  • Daniel J. Gibbs & Seung Cho Lee & Nurulhikma Md Isa & Silvia Gramuglia & Takeshi Fukao & George W. Bassel & Cristina Sousa Correia & Françoise Corbineau & Frederica L. Theodoulou & Julia Bailey-Serres, 2011. "Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants," Nature, Nature, vol. 479(7373), pages 415-418, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7373:d:10.1038_nature10534
    DOI: 10.1038/nature10534
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    Cited by:

    1. Verna Van & Janae B. Brown & Corin R. O’Shea & Hannah Rosenbach & Ijaz Mohamed & Nna-Emeka Ejimogu & Toan S. Bui & Veronika A. Szalai & Kelly N. Chacón & Ingrid Span & Fangliang Zhang & Aaron T. Smith, 2023. "Iron-sulfur clusters are involved in post-translational arginylation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Agata Zubrycka & Charlene Dambire & Laura Dalle Carbonare & Gunjan Sharma & Tinne Boeckx & Kamal Swarup & Craig J. Sturrock & Brian S. Atkinson & Ranjan Swarup & Françoise Corbineau & Neil J. Oldham &, 2023. "ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Karen C. Heathcote & Thomas P. Keeley & Matti Myllykoski & Malin Lundekvam & Nina McTiernan & Salma Akter & Norma Masson & Peter J. Ratcliffe & Thomas Arnesen & Emily Flashman, 2024. "N-terminal cysteine acetylation and oxidation patterns may define protein stability," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Eric Linster & Francy L. Forero Ruiz & Pavlina Miklankova & Thomas Ruppert & Johannes Mueller & Laura Armbruster & Xiaodi Gong & Giovanna Serino & Matthias Mann & Rüdiger Hell & Markus Wirtz, 2022. "Cotranslational N-degron masking by acetylation promotes proteome stability in plants," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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