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Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Author

Listed:
  • Eun Bae Kim

    (Ewha Womans University)

  • Xiaodong Fang

    (BGI-Shenzhen)

  • Alexey A. Fushan

    (Ewha Womans University)

  • Zhiyong Huang

    (BGI-Shenzhen)

  • Alexei V. Lobanov

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Lijuan Han

    (BGI-Shenzhen)

  • Stefano M. Marino

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Xiaoqing Sun

    (BGI-Shenzhen)

  • Anton A. Turanov

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Pengcheng Yang

    (BGI-Shenzhen)

  • Sun Hee Yim

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Xiang Zhao

    (BGI-Shenzhen)

  • Marina V. Kasaikina

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Nina Stoletzki

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Chunfang Peng

    (BGI-Shenzhen)

  • Paz Polak

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Zhiqiang Xiong

    (BGI-Shenzhen)

  • Adam Kiezun

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Yabing Zhu

    (BGI-Shenzhen)

  • Yuanxin Chen

    (BGI-Shenzhen)

  • Gregory V. Kryukov

    (Brigham and Women’s Hospital, Harvard Medical School
    Broad Institute of Harvard and MIT)

  • Qiang Zhang

    (BGI-Shenzhen)

  • Leonid Peshkin

    (Harvard Medical School)

  • Lan Yang

    (BGI-Shenzhen)

  • Roderick T. Bronson

    (Rodent Histopathology Laboratory, Harvard Medical School)

  • Rochelle Buffenstein

    (University of Texas Health Science Center)

  • Bo Wang

    (BGI-Shenzhen)

  • Changlei Han

    (BGI-Shenzhen)

  • Qiye Li

    (BGI-Shenzhen)

  • Li Chen

    (BGI-Shenzhen)

  • Wei Zhao

    (BGI-Shenzhen)

  • Shamil R. Sunyaev

    (Brigham and Women’s Hospital, Harvard Medical School
    Broad Institute of Harvard and MIT)

  • Thomas J. Park

    (University of Illinois at Chicago)

  • Guojie Zhang

    (BGI-Shenzhen)

  • Jun Wang

    (BGI-Shenzhen
    Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
    University of Copenhagen)

  • Vadim N. Gladyshev

    (Ewha Womans University
    Brigham and Women’s Hospital, Harvard Medical School
    Broad Institute of Harvard and MIT)

Abstract

It's in the genes The mouse-sized naked mole rat (Heterocephalus glaber) is a very unusual mammal. It is a social animal, living in groups in burrows beneath arid African deserts. It can live for 30 or more years in atmospheres with low oxygen and high carbon dioxide, and is remarkably resistant to cancer. So the genome sequence, published in this issue, might be expected to contain some intriguing characteristics. Analysis of the genome and its transcriptome reveals unusual genomic features and molecular adaptations including strategies for improved genome stability, low mutation rate and improved protein maintenance. The data also reveal molecular adaptations consistent with poor visual function, poikilothermy, hairlessness, circadian rhythms, taste sensing and insensitivity to low oxygen.

Suggested Citation

  • Eun Bae Kim & Xiaodong Fang & Alexey A. Fushan & Zhiyong Huang & Alexei V. Lobanov & Lijuan Han & Stefano M. Marino & Xiaoqing Sun & Anton A. Turanov & Pengcheng Yang & Sun Hee Yim & Xiang Zhao & Mari, 2011. "Genome sequencing reveals insights into physiology and longevity of the naked mole rat," Nature, Nature, vol. 479(7372), pages 223-227, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7372:d:10.1038_nature10533
    DOI: 10.1038/nature10533
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    Cited by:

    1. Chris G. Faulkes & Thomas R. Eykyn & Jan Lj. Miljkovic & James D. Gilbert & Rebecca L. Charles & Hiran A. Prag & Nikayla Patel & Daniel W. Hart & Michael P. Murphy & Nigel C. Bennett & Dunja Aksentije, 2024. "Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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