IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v479y2011i7371d10.1038_nature10507.html
   My bibliography  Save this article

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

Author

Listed:
  • Yukiji Takeda

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven
    Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB
    Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, K. U. Leuven)

  • Sandra Costa

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven
    Life and Health Sciences Research Institute, Minho University)

  • Estelle Delamarre

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven)

  • Carmen Roncal

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven
    Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB
    Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, K. U. Leuven)

  • Rodrigo Leite de Oliveira

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven
    Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB
    Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, K. U. Leuven)

  • Mario Leonardo Squadrito

    (Angiogenesis and Tumor Targeting Unit and HSR-TIGET, San Raffaele Institute
    Vita-Salute University)

  • Veronica Finisguerra

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven)

  • Sofie Deschoemaeker

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven)

  • Françoise Bruyère

    (Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB
    Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, K. U. Leuven)

  • Mathias Wenes

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven)

  • Alexander Hamm

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven)

  • Jens Serneels

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven)

  • Julie Magat

    (Biomedical Magnetic Resonance Unit, Universite Catholique de Louvain)

  • Tapan Bhattacharyya

    (Rayne Institute, University College London
    Present addresses: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK (T.P.); The Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, CH-1015, Switzerland (M.D.P.).)

  • Andrey Anisimov

    (Molecular/Cancer Biology Laboratory, Research Programs Unit and Institute for Molecular Medicine, Biomedicum Helsinki)

  • Benedicte F. Jordan

    (Biomedical Magnetic Resonance Unit, Universite Catholique de Louvain)

  • Kari Alitalo

    (Molecular/Cancer Biology Laboratory, Research Programs Unit and Institute for Molecular Medicine, Biomedicum Helsinki)

  • Patrick Maxwell

    (Rayne Institute, University College London)

  • Bernard Gallez

    (Biomedical Magnetic Resonance Unit, Universite Catholique de Louvain)

  • Zhen W. Zhuang

    (Cardiovascular Medicine, Yale University School of Medicine)

  • Yoshihiko Saito

    (Nara Medical University)

  • Michael Simons

    (Cardiovascular Medicine, Yale University School of Medicine)

  • Michele De Palma

    (Angiogenesis and Tumor Targeting Unit and HSR-TIGET, San Raffaele Institute
    Present addresses: Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK (T.P.); The Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, CH-1015, Switzerland (M.D.P.).)

  • Massimiliano Mazzone

    (Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
    Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, K. U. Leuven)

Abstract

Blood-supply boost in ischaemia The cellular oxygen-sensing enyzme PHD2 uses oxygen to degrade hypoxia-inducible factor 1α. Using a mouse model of limb ischaemia, Takeda et al. link oxygen sensing through PHD2 to macrophage phenotype and arteriogenesis. They show that myeloid-cell-specific PHD2 haplodeficiency results in improved arteriogenesis after ischaemia owing to hyperactivation of NFκB signalling in the macrophages and the promotion of an M2-like repair phenotype. This suggests that PHD2 inhibition might promote collateral vascularization in patients who are at risk of limb or heart ischaemia.

Suggested Citation

  • Yukiji Takeda & Sandra Costa & Estelle Delamarre & Carmen Roncal & Rodrigo Leite de Oliveira & Mario Leonardo Squadrito & Veronica Finisguerra & Sofie Deschoemaeker & Françoise Bruyère & Mathias Wenes, 2011. "Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis," Nature, Nature, vol. 479(7371), pages 122-126, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7371:d:10.1038_nature10507
    DOI: 10.1038/nature10507
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10507
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10507?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xing Liu & Jinhua Tang & Zixuan Wang & Chunchun Zhu & Hongyan Deng & Xueyi Sun & Guangqing Yu & Fangjing Rong & Xiaoyun Chen & Qian Liao & Shuke Jia & Wen Liu & Huangyuan Zha & Sijia Fan & Xiaolian Ca, 2024. "Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:479:y:2011:i:7371:d:10.1038_nature10507. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.