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Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors

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  • Daniel Vasiliauskas

    (Center for Developmental Genetics, New York University)

  • Esteban O. Mazzoni

    (Center for Developmental Genetics, New York University
    Present addresses: Departments of Pathology, Neurology, and Neuroscience, Columbia University Medical Center, 630 West 168 Street, New York, New York 10032, USA (E.O.M.); Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland(S.G.S.); Department of Molecular Biology and Genetics, Bogazici University, 34342 Bebek, Istanbul, Turkey (A.C.).)

  • Simon G. Sprecher

    (Center for Developmental Genetics, New York University
    Present addresses: Departments of Pathology, Neurology, and Neuroscience, Columbia University Medical Center, 630 West 168 Street, New York, New York 10032, USA (E.O.M.); Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland(S.G.S.); Department of Molecular Biology and Genetics, Bogazici University, 34342 Bebek, Istanbul, Turkey (A.C.).)

  • Konstantin Brodetskiy

    (Center for Developmental Genetics, New York University)

  • Robert J. Johnston Jr

    (Center for Developmental Genetics, New York University)

  • Preetmoninder Lidder

    (Center for Developmental Genetics, New York University)

  • Nina Vogt

    (Center for Developmental Genetics, New York University)

  • Arzu Celik

    (Center for Developmental Genetics, New York University
    Present addresses: Departments of Pathology, Neurology, and Neuroscience, Columbia University Medical Center, 630 West 168 Street, New York, New York 10032, USA (E.O.M.); Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland(S.G.S.); Department of Molecular Biology and Genetics, Bogazici University, 34342 Bebek, Istanbul, Turkey (A.C.).)

  • Claude Desplan

    (Center for Developmental Genetics, New York University)

Abstract

Cross-repression of sense receptors Some of the senses, such as colour vision and olfaction, rely on single sensory neurons to produce a specific chemical- or light-sensing G-protein coupled receptor. Various mechanisms have been proposed to explain exclusive gene expression in olfactory receptors, but the molecular pathways remain unknown. Claude Desplan and colleagues report that mature Drosophila R8 photoreceptors of the subtype that normally expresses green-sensing rhodopsin 6 protein can express the 'wrong' blue-sensing rhodopsin 5 when fruitflies are either kept in the dark or mutated in rhodopsin 6. Light thus achieves a negative feedback on the rh5 gene by repressing its transcription in rh6-expressing neurons, a system resembling the control of olfactory receptor genes in vertebrate olfactory neurons.

Suggested Citation

  • Daniel Vasiliauskas & Esteban O. Mazzoni & Simon G. Sprecher & Konstantin Brodetskiy & Robert J. Johnston Jr & Preetmoninder Lidder & Nina Vogt & Arzu Celik & Claude Desplan, 2011. "Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors," Nature, Nature, vol. 479(7371), pages 108-112, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7371:d:10.1038_nature10451
    DOI: 10.1038/nature10451
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    Cited by:

    1. Brian A. Hodge & Geoffrey T. Meyerhof & Subhash D. Katewa & Ting Lian & Charles Lau & Sudipta Bar & Nicole Y. Leung & Menglin Li & David Li-Kroeger & Simon Melov & Birgit Schilling & Craig Montell & P, 2022. "Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Pranidhi Sood & Robert J Johnston Jr. & Edo Kussell, 2012. "Stochastic De-repression of Rhodopsins in Single Photoreceptors of the Fly Retina," PLOS Computational Biology, Public Library of Science, vol. 8(2), pages 1-13, February.

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