Author
Listed:
- Carlo Colantuoni
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Johns Hopkins Bloomberg School of Public Health
Illuminato Biotechnology, Inc.
The Lieber Institute for Brain Development, Johns Hopkins University Medical Center)
- Barbara K. Lipska
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA)
- Tianzhang Ye
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA)
- Thomas M. Hyde
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
The Lieber Institute for Brain Development, Johns Hopkins University Medical Center)
- Ran Tao
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA)
- Jeffrey T. Leek
(Johns Hopkins Bloomberg School of Public Health)
- Elizabeth A. Colantuoni
(Johns Hopkins Bloomberg School of Public Health)
- Abdel G. Elkahloun
(Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health)
- Mary M. Herman
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA)
- Daniel R. Weinberger
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
The Lieber Institute for Brain Development, Johns Hopkins University Medical Center)
- Joel E. Kleinman
(Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA)
Abstract
Gene expression in the human brain Gene expression controls and dictates everything from development and plasticity to ongoing neurogenesis in the brain, yet the temporal dynamics of transcription throughout the brain's lifetime have been mostly unknown. Here, two groups present a large gene-expression database from a variety of human brain samples ranging from before birth to over 80 years in age. Colantuoni et al. focus on the prefrontal cortex. Although they note significant expression pattern dynamics throughout development, they identify a consistent molecular architecture of transcription across subjects from different races despite the large number of genetic polymorphisms among them. Kang et al. produce a more comprehensive time course, exploring expression in 16 different brain areas, determining that the largest spatiotemporal variability occurs before birth, with transcriptomes in brain regions converging as we age.
Suggested Citation
Carlo Colantuoni & Barbara K. Lipska & Tianzhang Ye & Thomas M. Hyde & Ran Tao & Jeffrey T. Leek & Elizabeth A. Colantuoni & Abdel G. Elkahloun & Mary M. Herman & Daniel R. Weinberger & Joel E. Kleinm, 2011.
"Temporal dynamics and genetic control of transcription in the human prefrontal cortex,"
Nature, Nature, vol. 478(7370), pages 519-523, October.
Handle:
RePEc:nat:nature:v:478:y:2011:i:7370:d:10.1038_nature10524
DOI: 10.1038/nature10524
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