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A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

Author

Listed:
  • Benjamin Beck

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Gregory Driessens

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Steven Goossens

    (Vascular Cell Biology Unit
    UGent Department for Molecular Biomedical Research)

  • Khalil Kass Youssef

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Anna Kuchnio

    (UGent Department for Molecular Biomedical Research
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB)

  • Amélie Caauwe

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Panagiota A. Sotiropoulou

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Sonja Loges

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K.U. Leuven
    Present address: Universitätsklinikum Hamburg-Eppendorf, II, Medical Clinic & Institute of Tumor Biology, Hamburg 20246, Germany.)

  • Gaelle Lapouge

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Aurélie Candi

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Guilhem Mascre

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Benjamin Drogat

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Sophie Dekoninck

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

  • Jody J. Haigh

    (Vascular Cell Biology Unit
    UGent Department for Molecular Biomedical Research)

  • Peter Carmeliet

    (Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB
    Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, K.U. Leuven)

  • Cédric Blanpain

    (IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
    Welbio, IRIBHM, Université Libre de Bruxelles, 808 route de Lennik)

Abstract

Targeting a cancer stem-cell niche Experiments in a mouse model of skin papillomas show that the tumour vasculature not only supplies blood, but also serves as a vascular niche environment that supports cancer stem cells. Vascular endothelial growth factor (VEGF) expression by tumour cells is important for angiogenesis, but also acts in an autocrine manner through its receptor to promote self-renewing divisions of cancer stem cells. Deletion of Nrp1 blocked the ability of VEGF to promote tumorigenesis, and may be a viable therapeutic target for skin cancers.

Suggested Citation

  • Benjamin Beck & Gregory Driessens & Steven Goossens & Khalil Kass Youssef & Anna Kuchnio & Amélie Caauwe & Panagiota A. Sotiropoulou & Sonja Loges & Gaelle Lapouge & Aurélie Candi & Guilhem Mascre & B, 2011. "A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours," Nature, Nature, vol. 478(7369), pages 399-403, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7369:d:10.1038_nature10525
    DOI: 10.1038/nature10525
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    Cited by:

    1. Durba Pal & Subhadip Ghatak & Kanhaiya Singh & Ahmed Safwat Abouhashem & Manishekhar Kumar & Mohamed S El Masry & Sujit K. Mohanty & Ravichand Palakurti & Yashika Rustagi & Saba Tabasum & Dolly K. Kho, 2023. "Identification of a physiologic vasculogenic fibroblast state to achieve tissue repair," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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