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Corridors of migrating neurons in the human brain and their decline during infancy

Author

Listed:
  • Nader Sanai

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
    University of California San Francisco
    Barrow Brain Tumor Research Center, Barrow Neurological Institute)

  • Thuhien Nguyen

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco)

  • Rebecca A. Ihrie

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco)

  • Zaman Mirzadeh

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
    Barrow Brain Tumor Research Center, Barrow Neurological Institute)

  • Hui-Hsin Tsai

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco)

  • Michael Wong

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco)

  • Nalin Gupta

    (University of California San Francisco)

  • Mitchel S. Berger

    (University of California San Francisco)

  • Eric Huang

    (University of California San Francisco)

  • Jose-Manuel Garcia-Verdugo

    (Laboratorio de Morfología Celular, Unidad Mixta CIPF-UVEG)

  • David H. Rowitch

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
    University of California San Francisco
    University of California San Francisco)

  • Arturo Alvarez-Buylla

    (Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
    University of California San Francisco)

Abstract

Neurogenesis in the infant brain In adult mammals, the subventricular zone is known to be one of the few sources for new neurons in the brain, but the contributions of these progenitors to distinct regions of the postnatal human brain are poorly understood. A study of human brain specimens from neurosurgical resections and autopsies ranging in age from birth to 84 years reveals extensive migration and proliferation of neuronal precursors along the rostral stream in human infants. After about 18 months of age, this subsides and is almost extinct in adulthood. During this limited time of neurogenesis, a novel stream of cells destined for the prefrontal cortex was also observed. These findings reconcile some conflicting reports in the literature and reveal new trajectories for tangentially migrating immature neurons during human brain development.

Suggested Citation

  • Nader Sanai & Thuhien Nguyen & Rebecca A. Ihrie & Zaman Mirzadeh & Hui-Hsin Tsai & Michael Wong & Nalin Gupta & Mitchel S. Berger & Eric Huang & Jose-Manuel Garcia-Verdugo & David H. Rowitch & Arturo , 2011. "Corridors of migrating neurons in the human brain and their decline during infancy," Nature, Nature, vol. 478(7369), pages 382-386, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7369:d:10.1038_nature10487
    DOI: 10.1038/nature10487
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    Cited by:

    1. Wei Liu & Xu Liao & Ziye Luo & Yi Yang & Mai Chan Lau & Yuling Jiao & Xingjie Shi & Weiwei Zhai & Hongkai Ji & Joe Yeong & Jin Liu, 2023. "Probabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Vanessa Donega & Astrid T. Geest & Jacqueline A. Sluijs & Roland E. Dijk & Chi Chiu Wang & Onur Basak & R. Jeroen Pasterkamp & Elly M. Hol, 2022. "Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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