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Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

Author

Listed:
  • Katey J. Rayner

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Christine C. Esau

    (Regulus Therapeutics)

  • Farah N. Hussain

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Allison L. McDaniel

    (Wake Forest University School of Medicine)

  • Stephanie M. Marshall

    (Wake Forest University School of Medicine)

  • Janine M. van Gils

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Tathagat D. Ray

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Frederick J. Sheedy

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Leigh Goedeke

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Xueqing Liu

    (Regulus Therapeutics)

  • Oleg G. Khatsenko

    (Regulus Therapeutics)

  • Vivek Kaimal

    (Regulus Therapeutics)

  • Cynthia J. Lees

    (Wake Forest University School of Medicine)

  • Carlos Fernandez-Hernando

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Edward A. Fisher

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

  • Ryan E. Temel

    (Wake Forest University School of Medicine)

  • Kathryn J. Moore

    (Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine)

Abstract

Manipulating plasma lipids Recent work in mice has shown that microRNA-33a is an important regulator of lipid metabolism and that its inhibition can increase plasma high-density lipoprotein (HDL) and decrease atherosclerosis. Rayner et al. take an important step in translating these findings to non-human primates (African green monkeys), which, like humans and unlike mice, express both miR-33a and miR-33b. They find that anti-miR-33 is effective at inhibiting both miR-33a and miR-33b. As seen in the mouse studies, anti-miR33 raised plasma HDL but had the additional beneficial effect of reducing very low-density lipoprotein triglycerides, making this type of 'antagomir' therapy a candidate method of treating dyslipidaemias that increase cardiovascular disease risk.

Suggested Citation

  • Katey J. Rayner & Christine C. Esau & Farah N. Hussain & Allison L. McDaniel & Stephanie M. Marshall & Janine M. van Gils & Tathagat D. Ray & Frederick J. Sheedy & Leigh Goedeke & Xueqing Liu & Oleg G, 2011. "Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides," Nature, Nature, vol. 478(7369), pages 404-407, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7369:d:10.1038_nature10486
    DOI: 10.1038/nature10486
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    Cited by:

    1. Nathan L. Price & Pablo Fernández-Tussy & Luis Varela & Magdalena P. Cardelo & Marya Shanabrough & Binod Aryal & Rafael Cabo & Yajaira Suárez & Tamas L. Horvath & Carlos Fernández-Hernando, 2024. "microRNA-33 controls hunger signaling in hypothalamic AgRP neurons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Nicolas Greliche & Tanja Zeller & Philipp S Wild & Maxime Rotival & Arne Schillert & Andreas Ziegler & Panos Deloukas & Jeanette Erdmann & Christian Hengstenberg & Willem H Ouwehand & Nilesh J Samani , 2012. "Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene Expression," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-12, September.

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