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Rahman et al. reply

Author

Listed:
  • Taufiq Rahman

    (Department of Pharmacology)

  • Alexander Skupin

    (Luxembourg Centre for Systems Biomedicine, 162a Avenue de la Faiencerie, University of Luxembourg
    Institute for Systems Biology, 401 Terry Avenue North)

  • Martin Falcke

    (§ Mathematical Cell Physiology, Max Delbruck Center for Molecular Medicine, Robert-Rössle-Str, 10, 13092 Berlin, Germany)

  • Colin W. Taylor

    (Department of Pharmacology)

Abstract

Replying to H. Vais, J. K. Foskett & D.-O. D. Mak Nature 478, doi:10.1038/nature10493 (2011) We observe that under conditions designed to mimic those of an unstimulated cell, InsP3 causes InsP3R to assemble rapidly and reversibly into small clusters of about 4–5 channels, and that gating of lone and clustered InsP3R by InsP3 and Ca2+ is different. We speculate that dynamic assembly of InsP3R clusters by InsP3 may contribute to the genesis of elementary Ca2+ release events by both assembling clusters and re-tuning the behaviour of InsP3R within them1,2,3. Vais et al.4 report that they have been unable to replicate some of our findings.

Suggested Citation

  • Taufiq Rahman & Alexander Skupin & Martin Falcke & Colin W. Taylor, 2011. "Rahman et al. reply," Nature, Nature, vol. 478(7368), pages 2-3, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7368:d:10.1038_nature10494
    DOI: 10.1038/nature10494
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    Cited by:

    1. Gotor, Elisabetta & Nedumaran, Swamikannu & Cenacchi, Nicola & Tran, Nhuong & Dunston, Shahnila & Dermawan, Ahmad & Valera, Harold Glenn & Wiberg, David & Tesfaye, Kindie & Mausch, Kai, 2021. "Land and Water Systems: Looking to the future and a more resilient and sustainable society and environment," SocArXiv ajs6q, Center for Open Science.

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