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Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

Author

Listed:
  • A. J. Ehrlicher

    (Brigham and Women’s Hospital, Harvard Medical School
    School of Engineering and Applied Sciences, Harvard University)

  • F. Nakamura

    (Brigham and Women’s Hospital, Harvard Medical School)

  • J. H. Hartwig

    (Brigham and Women’s Hospital, Harvard Medical School)

  • D. A. Weitz

    (School of Engineering and Applied Sciences, Harvard University)

  • T. P. Stossel

    (Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Mechanosensing by the actin cytoskeleton Living cells need to respond to mechanical forces for many essential biological functions. This mechanosensing activity is thought to be a property of the actin cytoskeleton, but no specific mechanisms have yet been identified. In this study, Ehrlicher et al. identify the actin-binding protein filamin A (FLNa) as a central mechanotransduction element. In a minimal reconstituted system, ligand binding to filamin is affected by mechanical forces, causing certain binding partners to dissociate and others to adhere more strongly. This selectivity may provide a direct molecular link between physical forces and biological activity.

Suggested Citation

  • A. J. Ehrlicher & F. Nakamura & J. H. Hartwig & D. A. Weitz & T. P. Stossel, 2011. "Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A," Nature, Nature, vol. 478(7368), pages 260-263, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7368:d:10.1038_nature10430
    DOI: 10.1038/nature10430
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    Cited by:

    1. Sorosh Amiri & Camelia Muresan & Xingbo Shang & Clotilde Huet-Calderwood & Martin A. Schwartz & David A. Calderwood & Michael Murrell, 2023. "Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Serena Petracchini & Daniel Hamaoui & Anne Doye & Atef Asnacios & Florian Fage & Elisa Vitiello & Martial Balland & Sebastien Janel & Frank Lafont & Mukund Gupta & Benoit Ladoux & Jerôme Gilleron & Te, 2022. "Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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