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Why tumours eat tryptophan

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  • George C. Prendergast

    (George C. Prendergast is in the Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA.)

Abstract

Tumours increase their consumption of the amino acid tryptophan to evade immune control. But how does this work? A study shows that the main product of this consumption binds to a receptor involved in the immune system. See Article p.197

Suggested Citation

  • George C. Prendergast, 2011. "Why tumours eat tryptophan," Nature, Nature, vol. 478(7368), pages 192-194, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7368:d:10.1038_478192a
    DOI: 10.1038/478192a
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    Cited by:

    1. Dongni Shi & Xianqiu Wu & Yunting Jian & Junye Wang & Chengmei Huang & Shuang Mo & Yue Li & Fengtian Li & Chao Zhang & Dongsheng Zhang & Huizhong Zhang & Huilin Huang & Xin Chen & Y. Alan Wang & Chuyo, 2022. "USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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