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Dynamics of human adipose lipid turnover in health and metabolic disease

Author

Listed:
  • Peter Arner

    (Karolinska University Hospital)

  • Samuel Bernard

    (Institut Camille Jordan, CNRS UMR 5208, University of Lyon)

  • Mehran Salehpour

    (Ion Physics, Uppsala University)

  • Göran Possnert

    (Ion Physics, Uppsala University)

  • Jakob Liebl

    (Faculty of Physics – Isotope Research, University of Vienna)

  • Peter Steier

    (Faculty of Physics – Isotope Research, University of Vienna)

  • Bruce A. Buchholz

    (Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, 7000 East Ave., L-397)

  • Mats Eriksson

    (Karolinska University Hospital)

  • Erik Arner

    (Karolinska University Hospital)

  • Hans Hauner

    (Else Kröner-Fresenius Centre for Nutritional Medicine, Technische Universität Münich)

  • Thomas Skurk

    (Else Kröner-Fresenius Centre for Nutritional Medicine, Technische Universität Münich)

  • Mikael Rydén

    (Karolinska University Hospital)

  • Keith N. Frayn

    (Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital)

  • Kirsty L. Spalding

    (Karolinska Institute, SE-171 77)

Abstract

Long-term lipid turnover in adipose tissue Lipid turnover is an important factor in determining how adipose tissue stores and releases energy in humans. By measuring carbon-14, derived from nuclear bomb tests, in the fat-cell lipids of a large cohort of individuals, Arner et al. estimate lipid turnover over a prolonged period in sickness and in health. The data show that during the ten-year lifespan of a typical human adipocyte, its triglyceride content is renewed six times. Unusual lipid turnover patterns correlate to conditions with disturbed lipid metabolism, suggesting it as a potential target for the treatment of metabolic disease.

Suggested Citation

  • Peter Arner & Samuel Bernard & Mehran Salehpour & Göran Possnert & Jakob Liebl & Peter Steier & Bruce A. Buchholz & Mats Eriksson & Erik Arner & Hans Hauner & Thomas Skurk & Mikael Rydén & Keith N. Fr, 2011. "Dynamics of human adipose lipid turnover in health and metabolic disease," Nature, Nature, vol. 478(7367), pages 110-113, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7367:d:10.1038_nature10426
    DOI: 10.1038/nature10426
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    Cited by:

    1. Alastair G. Kerr & Zuoneng Wang & Na Wang & Kelvin H. M. Kwok & Jutta Jalkanen & Alison Ludzki & Simon Lecoutre & Dominique Langin & Martin O. Bergo & Ingrid Dahlman & Carsten Mim & Peter Arner & Hui , 2022. "The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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