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Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

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  • Eric M. Kofoed

    (University of California)

  • Russell E. Vance

    (University of California)

Abstract

Pathogen specificity in innate immunity The inflammasomes are multiprotein complexes involved in innate immunity, and induce an immune response to pathogenic microbes by activating the caspase 1 protease. Two groups now report that the intracellular receptors known as NAIPs (NLR family, apoptosis inhibitory proteins), previously thought to have an auxiliary role in recognizing microbial proteins, are in fact central to the process. Eric Kofoed and Russell Vance, and Feng Shao and colleagues, show that different members of the NAIP family bind to different bacterial ligands, including bacterial flagellin and a conserved bacterial type III secretion system rod protein.

Suggested Citation

  • Eric M. Kofoed & Russell E. Vance, 2011. "Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity," Nature, Nature, vol. 477(7366), pages 592-595, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7366:d:10.1038_nature10394
    DOI: 10.1038/nature10394
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    Cited by:

    1. Shouya Feng & Daniel Enosi Tuipulotu & Abhimanu Pandey & Weidong Jing & Cheng Shen & Chinh Ngo & Melkamu B. Tessema & Fei-Ju Li & Daniel Fox & Anukriti Mathur & Anyang Zhao & Runli Wang & Klaus Pfeffe, 2022. "Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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