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Different patterns of peripheral migration by memory CD4+ and CD8+ T cells

Author

Listed:
  • Thomas Gebhardt

    (The University of Melbourne)

  • Paul G. Whitney

    (The University of Melbourne)

  • Ali Zaid

    (The University of Melbourne)

  • Laura K. Mackay

    (The University of Melbourne)

  • Andrew G. Brooks

    (The University of Melbourne)

  • William R. Heath

    (The University of Melbourne)

  • Francis R. Carbone

    (The University of Melbourne)

  • Scott N. Mueller

    (The University of Melbourne)

Abstract

T-cell migration is subset-specific T cells are crucial to immunity at surface tissues such as skin, which represent entry points for many infectious agents. Migration and targeting to these specific regions is thought to be a key to efficient immune protection. Gebhardt et al. provide evidence for differential migration of helper and killer T-cell subsets after local skin infection with herpes simplex virus, with helper and killer memory T cells segregating to dermis and epidermis respectively. CD4+ T cells, through their ability to access the circulation, are thought to be responsible for providing protection distal to the primary site of infection.

Suggested Citation

  • Thomas Gebhardt & Paul G. Whitney & Ali Zaid & Laura K. Mackay & Andrew G. Brooks & William R. Heath & Francis R. Carbone & Scott N. Mueller, 2011. "Different patterns of peripheral migration by memory CD4+ and CD8+ T cells," Nature, Nature, vol. 477(7363), pages 216-219, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7363:d:10.1038_nature10339
    DOI: 10.1038/nature10339
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    Cited by:

    1. Yasmin Jaber & Yasmine Netanely & Reem Naamneh & Or Saar & Khaled Zubeidat & Yasmin Saba & Olga Georgiev & Paz Kles & Or Barel & Yael Horev & Omri Yosef & Luba Eli-Berchoer & Chen Nadler & Gili Betser, 2023. "Langerhans cells shape postnatal oral homeostasis in a mechanical-force-dependent but microbiota and IL17-independent manner," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Curtis J. Pritzl & Dezzarae Luera & Karin M. Knudson & Michael J. Quaney & Michael J. Calcutt & Mark A. Daniels & Emma Teixeiro, 2023. "IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Sang T. Kim & Yanshuo Chu & Mercy Misoi & Maria E. Suarez-Almazor & Jean H. Tayar & Huifang Lu & Maryam Buni & Jordan Kramer & Emma Rodriguez & Zulekha Hussain & Sattva S. Neelapu & Jennifer Wang & Am, 2022. "Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Vitaly V Ganusov & Jeremy Auerbach, 2014. "Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism," PLOS Computational Biology, Public Library of Science, vol. 10(5), pages 1-15, May.

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