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TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

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Listed:
  • Mark C. Siracusa

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Steven A. Saenz

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • David A. Hill

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Brian S. Kim

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Mark B. Headley

    (Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, University of Washington School of Medicine)

  • Travis A. Doering

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • E. John Wherry

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Heidi K. Jessup

    (Inflammation Research, Amgen Inc.)

  • Lori A. Siegel

    (Inflammation Research, Amgen Inc.)

  • Taku Kambayashi

    (Perelman School of Medicine, University of Pennsylvania)

  • Emily C. Dudek

    (Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania)

  • Masato Kubo

    (Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute
    Research Institute for Biological Science, Tokyo University of Science)

  • Antonella Cianferoni

    (Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania)

  • Jonathan M. Spergel

    (Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania)

  • Steven F. Ziegler

    (Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, University of Washington School of Medicine)

  • Michael R. Comeau

    (Inflammation Research, Amgen Inc.)

  • David Artis

    (Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania
    School of Veterinary Medicine, University of Pennsylvania)

Abstract

TSLP's role in allergy The cytokine thymic stromal lymphopoietin (TSLP) has been described as the master switch of allergic inflammation. Here, TSLP is shown to induce the development of basophils from bone-marrow progenitors and to activate peripheral basophils in an interleukin-3 (IL-3)-independent manner. Basophils elicited by TSLP differ from those dependent on IL-3 both phenotypically and functionally, and may play an important part in allergic diseases associated with T-helper type 2 cells.

Suggested Citation

  • Mark C. Siracusa & Steven A. Saenz & David A. Hill & Brian S. Kim & Mark B. Headley & Travis A. Doering & E. John Wherry & Heidi K. Jessup & Lori A. Siegel & Taku Kambayashi & Emily C. Dudek & Masato , 2011. "TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation," Nature, Nature, vol. 477(7363), pages 229-233, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7363:d:10.1038_nature10329
    DOI: 10.1038/nature10329
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    Cited by:

    1. Kensuke Miyake & Junya Ito & Jun Nakabayashi & Shigeyuki Shichino & Kenji Ishiwata & Hajime Karasuyama, 2023. "Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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