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The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Author

Listed:
  • Saul A. Villeda

    (Stanford University School of Medicine
    Neuroscience IDP Program, Stanford University School of Medicine)

  • Jian Luo

    (Stanford University School of Medicine)

  • Kira I. Mosher

    (Stanford University School of Medicine
    Neuroscience IDP Program, Stanford University School of Medicine)

  • Bende Zou

    (AfaSci Research Laboratory)

  • Markus Britschgi

    (Stanford University School of Medicine
    Present addresses: CNS Discovery, pRED, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland (M.B.); Department of Biochemistry, College of Medicien, Dankook University, Cheonan 330-714, South Korea (J.S.P.).)

  • Gregor Bieri

    (Stanford University School of Medicine
    School of Life Sciences, Swiss Federal Institute of Technology (EPFL))

  • Trisha M. Stan

    (Stanford University School of Medicine
    Immunology IDP Program, Stanford University School of Medicine)

  • Nina Fainberg

    (Stanford University School of Medicine)

  • Zhaoqing Ding

    (Stanford University School of Medicine
    Immunology IDP Program, Stanford University School of Medicine)

  • Alexander Eggel

    (Stanford University School of Medicine)

  • Kurt M. Lucin

    (Stanford University School of Medicine)

  • Eva Czirr

    (Stanford University School of Medicine)

  • Jeong-Soo Park

    (Stanford University School of Medicine
    Present addresses: CNS Discovery, pRED, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland (M.B.); Department of Biochemistry, College of Medicien, Dankook University, Cheonan 330-714, South Korea (J.S.P.).)

  • Sebastien Couillard-Després

    (Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21)

  • Ludwig Aigner

    (Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21)

  • Ge Li

    (University of Washington School of Medicine)

  • Elaine R. Peskind

    (University of Washington School of Medicine
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center)

  • Jeffrey A. Kaye

    (Layton Aging and Alzheimer's Disease Center, Oregon Health and Science University, CR131, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201-3098, USA; and Portland VA Medical Center
    and Portland VA Medical Center)

  • Joseph F. Quinn

    (Layton Aging and Alzheimer's Disease Center, Oregon Health and Science University, CR131, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201-3098, USA; and Portland VA Medical Center
    and Portland VA Medical Center)

  • Douglas R. Galasko

    (University of California San Diego, 9500 Gilman Drive 0948)

  • Xinmin S. Xie

    (AfaSci Research Laboratory)

  • Thomas A. Rando

    (Stanford University School of Medicine
    Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System
    The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine)

  • Tony Wyss-Coray

    (Stanford University School of Medicine
    Neuroscience IDP Program, Stanford University School of Medicine
    Immunology IDP Program, Stanford University School of Medicine
    Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System)

Abstract

Blood-borne factors affect the ageing brain Regenerative capacity and cognitive function decline during ageing. A study using heterochronic parabiosis, in which pairs of young and old mice are surgically joined by a shared blood supply, shows that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in ageing mice. A proteomic screen identified a subset of plasma signalling proteins that correlate with the decreased neurogenesis observed in both normal ageing and parabiosis. CCL11 (also known as eotoxin) and β2-microglobulin — factors classically involved in immune responses — were among the identified factors able to decrease progenitor frequency and neural differentiation.

Suggested Citation

  • Saul A. Villeda & Jian Luo & Kira I. Mosher & Bende Zou & Markus Britschgi & Gregor Bieri & Trisha M. Stan & Nina Fainberg & Zhaoqing Ding & Alexander Eggel & Kurt M. Lucin & Eva Czirr & Jeong-Soo Par, 2011. "The ageing systemic milieu negatively regulates neurogenesis and cognitive function," Nature, Nature, vol. 477(7362), pages 90-94, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7362:d:10.1038_nature10357
    DOI: 10.1038/nature10357
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    Cited by:

    1. Orestis Delardas & Panagiotis Giannos, 2023. "Cognitive Performance Deficits Are Associated with Clinically Significant Depression Symptoms in Older US Adults," IJERPH, MDPI, vol. 20(7), pages 1-10, March.
    2. Xu Zhang & Vesselina M. Pearsall & Chase M. Carver & Elizabeth J. Atkinson & Benjamin D. S. Clarkson & Ethan M. Grund & Michelle Baez-Faria & Kevin D. Pavelko & Jennifer M. Kachergus & Thomas A. White, 2022. "Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Felicia Lazure & Rick Farouni & Korin Sahinyan & Darren M. Blackburn & Aldo Hernández-Corchado & Gabrielle Perron & Tianyuan Lu & Adrien Osakwe & Jiannis Ragoussis & Colin Crist & Theodore J. Perkins , 2023. "Transcriptional reprogramming of skeletal muscle stem cells by the niche environment," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Di-Xian Wang & Zhao-Jun Dong & Sui-Xin Deng & Ying-Ming Tian & Yu-Jie Xiao & Xinran Li & Xiao-Ru Ma & Liang Li & Pengxiao Li & Hui-Zhong Chang & Longqi Liu & Fan Wang & Yang Wu & Xiang Gao & Shuang-Sh, 2023. "GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
    5. Alvaro Bustamante-Sanchez & Bella Esperanza Villegas-Mora & Ismael Martínez-Guardado & Jose Francisco Tornero-Aguilera & Luca Paolo Ardigò & Hadi Nobari & Vicente Javier Clemente-Suárez, 2022. "Physical Activity and Nutritional Pattern Related to Maturation and Development," Sustainability, MDPI, vol. 14(24), pages 1-22, December.
    6. Byung Jo Choi & Min Hee Park & Kang Ho Park & Wan Hui Han & Hee Ji Yoon & Hye Yoon Jung & Ju Yeon Hong & Md Riad Chowdhury & Kyung Yeol Kim & Jihoon Lee & Im-Sook Song & Minyeong Pang & Min-Koo Choi &, 2023. "Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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