IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v476y2011i7361d10.1038_nature10312.html
   My bibliography  Save this article

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation

Author

Listed:
  • Vlad C. Seitan

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
    Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Bingtao Hao

    (Duke University Medical Center)

  • Kikuë Tachibana-Konwalski

    (University of Oxford)

  • Thais Lavagnolli

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Hegias Mira-Bontenbal

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Karen E. Brown

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Grace Teng

    (Yale University School of Medicine)

  • Tom Carroll

    (Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Anna Terry

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Katie Horan

    (Central Biological Services, Imperial College London)

  • Hendrik Marks

    (Nijmegen Center for Molecular Life Sciences, Radboud University)

  • David J. Adams

    (Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • David G. Schatz

    (Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University School of Medicine)

  • Luis Aragon

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Amanda G. Fisher

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

  • Michael S. Krangel

    (Duke University Medical Center)

  • Kim Nasmyth

    (University of Oxford)

  • Matthias Merkenschlager

    (Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
    Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London)

Abstract

Cohesin role in T-cell differentiation Cohesin is well known as the protein complex that holds sister chromatids together after replication so that they are not prematurely separated before mitosis. More recent data suggested that cohesin also has a cell-division-independent function, the loss of which can lead to disease. Matthias Merkenschlager and colleagues report that in mouse thymocytes, cohesin is required for long-range interactions that underlie several events leading to T-cell receptor rearrangement and thymocyte differentiation.

Suggested Citation

  • Vlad C. Seitan & Bingtao Hao & Kikuë Tachibana-Konwalski & Thais Lavagnolli & Hegias Mira-Bontenbal & Karen E. Brown & Grace Teng & Tom Carroll & Anna Terry & Katie Horan & Hendrik Marks & David J. Ad, 2011. "A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation," Nature, Nature, vol. 476(7361), pages 467-471, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7361:d:10.1038_nature10312
    DOI: 10.1038/nature10312
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10312
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10312?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tomas Zelenka & Antonios Klonizakis & Despina Tsoukatou & Dionysios-Alexandros Papamatheakis & Sören Franzenburg & Petros Tzerpos & Ioannis-Rafail Tzonevrakis & George Papadogkonas & Manouela Kapsetak, 2022. "The 3D enhancer network of the developing T cell genome is shaped by SATB1," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:476:y:2011:i:7361:d:10.1038_nature10312. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.