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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Author

Listed:
  • Joshua M. Baughman

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Fabiana Perocchi

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Hany S. Girgis

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Molly Plovanich

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Casey A. Belcher-Timme

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Yasemin Sancak

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • X. Robert Bao

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Laura Strittmatter

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Olga Goldberger

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

  • Roman L. Bogorad

    (Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Victor Koteliansky

    (Alnylam Pharmaceuticals, Inc.)

  • Vamsi K. Mootha

    (Harvard Medical School and Massachusetts General Hospital
    Broad Institute)

Abstract

Mitochondrial Ca2+ channel identified Central to the role of the mitochondrion in cellular metabolism is its ability to control the fluxes of the key signalling ion, Ca2+. This is done by a highly selective ion channel known as the mitochondrial calcium uniporter. The molecular nature of this channel has remained elusive, but now two groups report the identification of a 40-kilodalton protein in the inner membrane of mitochondria as the active channel of the uniporter. This protein contains two transmembrane domains and exhibits calcium-channel activity in vitro and in vivo.

Suggested Citation

  • Joshua M. Baughman & Fabiana Perocchi & Hany S. Girgis & Molly Plovanich & Casey A. Belcher-Timme & Yasemin Sancak & X. Robert Bao & Laura Strittmatter & Olga Goldberger & Roman L. Bogorad & Victor Ko, 2011. "Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter," Nature, Nature, vol. 476(7360), pages 341-345, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7360:d:10.1038_nature10234
    DOI: 10.1038/nature10234
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    Cited by:

    1. Enrique Balderas & David R. Eberhardt & Sandra Lee & John M. Pleinis & Salah Sommakia & Anthony M. Balynas & Xue Yin & Mitchell C. Parker & Colin T. Maguire & Scott Cho & Marta W. Szulik & Anna Bakhti, 2022. "Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Doron Stupp & Elad Sharon & Idit Bloch & Marinka Zitnik & Or Zuk & Yuval Tabach, 2021. "Co-evolution based machine-learning for predicting functional interactions between human genes," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Mohammad Naimul Islam & Galina A. Gusarova & Shonit R. Das & Li Li & Eiji Monma & Murari Anjaneyulu & Liberty Mthunzi & Sadiqa K. Quadri & Edward Owusu-Ansah & Sunita Bhattacharya & Jahar Bhattacharya, 2022. "The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Deborah Mesa & Elisa Barbieri & Andrea Raimondi & Stefano Freddi & Giorgia Miloro & Gorana Jendrisek & Giusi Caldieri & Micaela Quarto & Irene Schiano Lomoriello & Maria Grazia Malabarba & Arianna Bre, 2024. "A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Caterina Marchioretti & Giulia Zanetti & Marco Pirazzini & Gaia Gherardi & Leonardo Nogara & Roberta Andreotti & Paolo Martini & Lorenzo Marcucci & Marta Canato & Samir R. Nath & Emanuela Zuccaro & Ma, 2023. "Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Hans J C T Wessels & Rutger O Vogel & Robert N Lightowlers & Johannes N Spelbrink & Richard J Rodenburg & Lambert P van den Heuvel & Alain J van Gool & Jolein Gloerich & Jan A M Smeitink & Leo G Nijtm, 2013. "Analysis of 953 Human Proteins from a Mitochondrial HEK293 Fraction by Complexome Profiling," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-14, July.
    7. Mariana P. Cervantes-Silva & Richard G. Carroll & Mieszko M. Wilk & Diana Moreira & Cloe A. Payet & James R. O’Siorain & Shannon L. Cox & Lauren E. Fagan & Paula A. Klavina & Yan He & Tabea Drewinski , 2022. "The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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