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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Author

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  • Diego De Stefani

    (University of Padua, 35121 Padua, Italy
    CNR Institute of Neuroscience, University of Padua, 35121 Padua, Italy)

  • Anna Raffaello

    (University of Padua, 35121 Padua, Italy
    CNR Institute of Neuroscience, University of Padua, 35121 Padua, Italy)

  • Enrico Teardo

    (University of Padua, 35121 Padua, Italy)

  • Ildikò Szabò

    (University of Padua, 35121 Padua, Italy)

  • Rosario Rizzuto

    (University of Padua, 35121 Padua, Italy
    CNR Institute of Neuroscience, University of Padua, 35121 Padua, Italy)

Abstract

Mitochondrial Ca2+ channel identified Central to the role of the mitochondrion in cellular metabolism is its ability to control the fluxes of the key signalling ion, Ca2+. This is done by a highly selective ion channel known as the mitochondrial calcium uniporter. The molecular nature of this channel has remained elusive, but now two groups report the identification of a 40-kilodalton protein in the inner membrane of mitochondria as the active channel of the uniporter. This protein contains two transmembrane domains and exhibits calcium-channel activity in vitro and in vivo.

Suggested Citation

  • Diego De Stefani & Anna Raffaello & Enrico Teardo & Ildikò Szabò & Rosario Rizzuto, 2011. "A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter," Nature, Nature, vol. 476(7360), pages 336-340, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7360:d:10.1038_nature10230
    DOI: 10.1038/nature10230
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    Cited by:

    1. Deborah Mesa & Elisa Barbieri & Andrea Raimondi & Stefano Freddi & Giorgia Miloro & Gorana Jendrisek & Giusi Caldieri & Micaela Quarto & Irene Schiano Lomoriello & Maria Grazia Malabarba & Arianna Bre, 2024. "A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Enrique Balderas & David R. Eberhardt & Sandra Lee & John M. Pleinis & Salah Sommakia & Anthony M. Balynas & Xue Yin & Mitchell C. Parker & Colin T. Maguire & Scott Cho & Marta W. Szulik & Anna Bakhti, 2022. "Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Eunbyul Cho & Youngsik Woo & Yeongjun Suh & Bo Kyoung Suh & Soo Jeong Kim & Truong Thi My Nhung & Jin Yeong Yoo & Tran Diem Nghi & Su Been Lee & Dong Jin Mun & Sang Ki Park, 2023. "Ratiometric measurement of MAM Ca2+ dynamics using a modified CalfluxVTN," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Mohammad Naimul Islam & Galina A. Gusarova & Shonit R. Das & Li Li & Eiji Monma & Murari Anjaneyulu & Liberty Mthunzi & Sadiqa K. Quadri & Edward Owusu-Ansah & Sunita Bhattacharya & Jahar Bhattacharya, 2022. "The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Caterina Marchioretti & Giulia Zanetti & Marco Pirazzini & Gaia Gherardi & Leonardo Nogara & Roberta Andreotti & Paolo Martini & Lorenzo Marcucci & Marta Canato & Samir R. Nath & Emanuela Zuccaro & Ma, 2023. "Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Mariana P. Cervantes-Silva & Richard G. Carroll & Mieszko M. Wilk & Diana Moreira & Cloe A. Payet & James R. O’Siorain & Shannon L. Cox & Lauren E. Fagan & Paula A. Klavina & Yan He & Tabea Drewinski , 2022. "The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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