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The landscape of recombination in African Americans

Author

Listed:
  • Anjali G. Hinch

    (Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK.)

  • Arti Tandon

    (Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
    Deptartment of Genetics, Harvard Medical School, New Research Building, 77 Ave. Louis Pasteur, Boston, Massachusetts 02115, USA.)

  • Nick Patterson

    (Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.)

  • Yunli Song

    (Oxford University, 1 South Parks Road, Oxford OX1 3TG, UK.)

  • Nadin Rohland

    (Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
    Deptartment of Genetics, Harvard Medical School, New Research Building, 77 Ave. Louis Pasteur, Boston, Massachusetts 02115, USA.)

  • Cameron D. Palmer

    (Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
    Children’s Hospital Boston, Massachusetts 02115, USA.)

  • Gary K. Chen

    (Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center)

  • Kai Wang

    (Zilkha Neurogenetic Institute, University of Southern California
    Center for Applied Genomics, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.)

  • Sarah G. Buxbaum

    (Jackson Heart Study Coordinating Center, Jackson State University, 350 W. Woodrow Wilson Ave., Suite 701, Jackson, Mississippi 39213, USA.)

  • Ermeg L. Akylbekova

    (Jackson Heart Study Coordinating Center, Jackson State University, 350 W. Woodrow Wilson Ave., Suite 701, Jackson, Mississippi 39213, USA.
    University of Mississippi Medical Center, 2500 N. State St., Jackson, Mississippi 39216, USA.)

  • Melinda C. Aldrich

    (Vanderbilt University School of Medicine
    Vanderbilt Epidemiology Center; and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Christine B. Ambrosone

    (Roswell Park Cancer Institute)

  • Christopher Amos

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.)

  • Elisa V. Bandera

    (The Cancer Institute of New Jersey)

  • Sonja I. Berndt

    (National Cancer Institute)

  • Leslie Bernstein

    (Beckman Research Institute, City of Hope, California 91010, USA.)

  • William J. Blot

    (Vanderbilt Epidemiology Center; and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    International Epidemiology Institute)

  • Cathryn H. Bock

    (Wayne State University of Medicine)

  • Eric Boerwinkle

    (University of Texas at Houston, 1200 Herman Pressler St., Houston, Texas 77030, USA.)

  • Qiuyin Cai

    (Vanderbilt Epidemiology Center; and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Neil Caporaso

    (National Cancer Institute)

  • Graham Casey

    (Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center)

  • L. Adrienne Cupples

    (Boston University School of Public Health, 801 Massachusetts Avenue, Boston, Massachusetts 02118 and Framingham Heart Study, Framingham, Massachusetts 01702, USA.)

  • Sandra L. Deming

    (Vanderbilt Epidemiology Center; and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • W. Ryan Diver

    (Epidemiology Research Program, American Cancer Society)

  • Jasmin Divers

    (Wake Forest University School of Medicine WC-2326, Medical Center Blvd., Winston Salem, North Carolina 27157, USA.)

  • Myriam Fornage

    (School of Public Health, University of Texas Health Sciences Center at Houston, 1825 Pressler Street, Houston, Texas 77030, USA.)

  • Elizabeth M. Gillanders

    (National Cancer Institute)

  • Joseph Glessner

    (Center for Applied Genomics, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.)

  • Curtis C. Harris

    (Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute)

  • Jennifer J. Hu

    (University of Miami Miller School of Medicine)

  • Sue A. Ingles

    (Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center)

  • William Isaacs

    (James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institutions)

  • Esther M. John

    (Cancer Prevention Institute of California, Fremont, California 94538; and Stanford University School of Medicine and Stanford Cancer Center, Stanford, California 94305, USA.
    and Stanford University School of Medicine and Stanford Cancer Center, Stanford, California 94305, USA.)

  • W. H. Linda Kao

    (Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, Maryland 21205, USA.)

  • Brendan Keating

    (Center for Applied Genomics, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.)

  • Rick A. Kittles

    (University of Illinois at Chicago)

  • Laurence N. Kolonel

    (Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.)

  • Emma Larkin

    (Pulmonary and Critical Care, 6100 Medical Center East, Vanderbilt University Medical Center, Nashville, Tennessee 37232-8300, USA.)

  • Loic Le Marchand

    (Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.)

  • Lorna H. McNeill

    (Cancer Prevention and Population Sciences, and Center for Community Implementation and Dissemination Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center)

  • Robert C. Millikan

    (Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center, University of North Carolina)

  • Murphy

    (Northwestern University)

  • Solomon Musani

    (University of Mississippi Medical Center, 2500 N. State St., Jackson, Mississippi 39216, USA.)

  • Christine Neslund-Dudas

    (Henry Ford Hospital)

  • Sarah Nyante

    (Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center, University of North Carolina)

  • George J. Papanicolaou

    (National Heart, Lung and Blood Institute, 6701 Rockledge Drive, Bethesda, Maryland 20892, USA.)

  • Michael F. Press

    (Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center)

  • Bruce M. Psaty

    (Cardiovascular Health Research Unit, Epidemiology & Health Services, University of Washington; Group Health Cooperative; 1730 Minor Ave., Seattle, Washington 98101, USA.
    Group Health Research Institute)

  • Alex P. Reiner

    (University of Washington, Box 357236 Seattle, Washington 98195, USA.)

  • Stephen S. Rich

    (Center for Public Health Genomics, University of Virginia, West Complex Room 6111, Charlottesville, Virginia 22908, USA.)

  • Jorge L. Rodriguez-Gil

    (University of Miami Miller School of Medicine)

  • Jerome I. Rotter

    (Medical Genetics Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, California 90048, USA.)

  • Benjamin A. Rybicki

    (Henry Ford Hospital)

  • Ann G. Schwartz

    (Wayne State University of Medicine)

  • Lisa B. Signorello

    (Vanderbilt Epidemiology Center; and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    International Epidemiology Institute)

  • Margaret Spitz

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.)

  • Sara S. Strom

    (The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.)

  • Michael J. Thun

    (Epidemiology Research Program, American Cancer Society)

  • Margaret A. Tucker

    (National Cancer Institute)

  • Zhaoming Wang

    (Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick)

  • John K. Wiencke

    (University of California San Francisco, San Francisco, California 94158, USA.)

  • John S. Witte

    (Institute for Human Genetics, University of California)

  • Margaret Wrensch

    (University of California San Francisco, San Francisco, California 94158, USA.)

  • Xifeng Wu

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.)

  • Yuko Yamamura

    (The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.)

  • Krista A. Zanetti

    (National Cancer Institute
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute)

  • Wei Zheng

    (Vanderbilt Epidemiology Center; and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
    and the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Regina G. Ziegler

    (National Cancer Institute)

  • Xiaofeng Zhu

    (School of Medicine, Case Western Reserve University, Wolstein Research Building, Cleveland, Ohio 4106, USA.)

  • Susan Redline

    (Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA.)

  • Joel N. Hirschhorn

    (Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
    Children’s Hospital Boston, Massachusetts 02115, USA.
    Harvard Medical School)

  • Brian E. Henderson

    (Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center)

  • Herman A. Taylor Jr

    (University of Mississippi Medical Center, 2500 N. State St., Jackson, Mississippi 39216, USA.
    Jackson State University, 1400 Lynch Street, Jackson, Mississippi 39217, USA.
    Tougaloo College, 500 West County Line Road, Tougaloo, Mississippi 39174, USA.)

  • Alkes L. Price

    (Harvard School of Public Health)

  • Hakon Hakonarson

    (Center for Applied Genomics, The Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
    University of Pennsylvania School of Medicine)

  • Stephen J. Chanock

    (National Cancer Institute)

  • Christopher A. Haiman

    (Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center)

  • James G. Wilson

    (University of Mississippi Medical Center, 2500 N. State St., Jackson, Mississippi 39216, USA.)

  • David Reich

    (Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
    Deptartment of Genetics, Harvard Medical School, New Research Building, 77 Ave. Louis Pasteur, Boston, Massachusetts 02115, USA.)

  • Simon R. Myers

    (Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK.
    Oxford University, 1 South Parks Road, Oxford OX1 3TG, UK.)

Abstract

Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P value

Suggested Citation

  • Anjali G. Hinch & Arti Tandon & Nick Patterson & Yunli Song & Nadin Rohland & Cameron D. Palmer & Gary K. Chen & Kai Wang & Sarah G. Buxbaum & Ermeg L. Akylbekova & Melinda C. Aldrich & Christine B. A, 2011. "The landscape of recombination in African Americans," Nature, Nature, vol. 476(7359), pages 170-175, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7359:d:10.1038_nature10336
    DOI: 10.1038/nature10336
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    1. Rui Wang & Peng Zhang & Xin Lv & Lingling Jiang & Chunshi Gao & Yuanyuan Song & Yaqin Yu & Bo Li, 2016. "Situation of Diabetes and Related Disease Surveillance in Rural Areas of Jilin Province, Northeast China," IJERPH, MDPI, vol. 13(6), pages 1-10, May.
    2. Rong Su & Le Cai & Wenlong Cui & Jianhui He & Dingyun You & Allison Golden, 2016. "Multilevel Analysis of Socioeconomic Determinants on Diabetes Prevalence, Awareness, Treatment and Self-Management in Ethnic Minorities of Yunnan Province, China," IJERPH, MDPI, vol. 13(8), pages 1-12, July.
    3. Owen Alexander Higgins & Alessandra Modi & Costanza Cannariato & Maria Angela Diroma & Federico Lugli & Stefano Ricci & Valentina Zaro & Stefania Vai & Antonino Vazzana & Matteo Romandini & He Yu & Fr, 2024. "Life history and ancestry of the late Upper Palaeolithic infant from Grotta delle Mura, Italy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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