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DMRT1 prevents female reprogramming in the postnatal mammalian testis

Author

Listed:
  • Clinton K. Matson

    (Cell Biology, and Development, University of Minnesota
    Molecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota)

  • Mark W. Murphy

    (Cell Biology, and Development, University of Minnesota)

  • Aaron L. Sarver

    (University of Minnesota Masonic Cancer Center)

  • Michael D. Griswold

    (School of Molecular Biosciences, Washington State University)

  • Vivian J. Bardwell

    (Cell Biology, and Development, University of Minnesota
    Molecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota
    University of Minnesota Masonic Cancer Center)

  • David Zarkower

    (Cell Biology, and Development, University of Minnesota
    Molecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota
    University of Minnesota Masonic Cancer Center)

Abstract

DMRT1 loss is cue for sex swap The presence or absence of the Y-chromosome gene Sry determines whether precursor cells differentiate into testicular Sertoli cells or ovarian granulosa cells in the mammalian fetus. Loss of the transcription factor FOXL2 in the adult ovary can lead to transdifferentiation of granulosa cells into Sertoli cells, but in males the sex-determining decision was thought to be stable. This study shows that this is not the case: adult mouse testicular cells become ovarian cells if the Dmrt1 gene is lost. In the absence of transcription factor DMRT1, FOXL2 is activated and Sertoli cells are reprogrammed as granulosa cells.

Suggested Citation

  • Clinton K. Matson & Mark W. Murphy & Aaron L. Sarver & Michael D. Griswold & Vivian J. Bardwell & David Zarkower, 2011. "DMRT1 prevents female reprogramming in the postnatal mammalian testis," Nature, Nature, vol. 476(7358), pages 101-104, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7358:d:10.1038_nature10239
    DOI: 10.1038/nature10239
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    Cited by:

    1. Karina F. Rodriguez & Paula R. Brown & Ciro M. Amato & Barbara Nicol & Chia-Feng Liu & Xin Xu & Humphrey Hung-Chang Yao, 2022. "Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Xiaowei Gu & Anna Heinrich & Shu-Yun Li & Tony DeFalco, 2023. "Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Moïra Rossitto & Stephanie Déjardin & Chris M. Rands & Stephanie Gras & Roberta Migale & Mahmoud-Reza Rafiee & Yasmine Neirijnck & Alain Pruvost & Anvi Laetitia Nguyen & Guillaume Bossis & Florence Ca, 2022. "TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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